Results 161 to 170 of about 294,445 (234)

Acute Respiratory Distress Syndrome Secondary to Influenza A Infection in a Patient With No Significant Risk Factors: A Case Report. [PDF]

Cureus
Khouri A, Helou M, Haj Hussein A, Tanios A, Nakhle R.   +4 more
europepmc   +1 more source

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Aging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu   +8 more
wiley   +1 more source

Patients in hospital with confirmed bacterial airway infection are significantly more likely to have a respiratory virus co-infection. [PDF]

J Med Microbiol
Hamza YP, Kacem MABH, Al Molawi NH, Yassine HM, AlKhatib HAM, Benslimane F, Al-Remaihi HIKB, Awni El Kahlout R, Ahmed El Kahlout BI, Al Khalili H, Al Khalili MA, Doiphode SH, Elmagboul EBI, Akhter J, Al Kuwari EAE, Coyle PV.   +15 more
europepmc   +1 more source

Virus‐Induced Cellular Senescence Causes Pulmonary Sequelae Post‐Influenza Infection

Aging Cell, EarlyView.
Genetic or pharmacological depletion of senescent cells during influenza A virus infection led to complete recovery of the airway epithelium, indicating a marked acceleration of the epithelial repair process. Targeting senescent cells may represent a new preventive therapeutic option to reduce post‐influenza chronic lung damage.
Larissa Lipskaia, Lou Delval, Valentin Sencio, Emmanuelle Born, Séverine Heumel, Amal Houssaini, Clara Valentin, Stefano Raviola, Lucie Deruyter, Fabiola Silva Angulo, Vincent Gros, Elisabeth Marcos, Shariq Abid, Mira Goekyildirim, Vanessa Contreras, Jean Michel Flaman, Roger Le Grand, Ronan Le Goffic, David Bernard, Serge Adnot, François Trottein   +20 more
wiley   +1 more source

Pneumococcal density and respiratory co-detection in severe pediatric pneumonia in Laos. [PDF]

Sci Rep
Dubot-Pérès A, Lee SJ, Dance DAB, Satzke C, Moore K, Pell CL, Ortika BD, Nation ML, Dunne EM, Vilivong K, Bounkhoun T, Phommachan S, Lim R, Lai J, Morpeth M, Mayxay M, de Lamballerie X, Newton PN, Russell FM.   +18 more
europepmc   +1 more source

Impaired Cytokine Secretion Contributes to Age‐Dependent Immune Dysfunction in SARS Coronavirus Response and Is Restored by Young CD11b‐Positive Cell Transfer

Aging Cell, EarlyView.
Aged CD11b+ cells exhibit impaired IRF7 activation and reduced SNARE protein expression, leading to delayed interferon responses and diminished cytokine secretion. These dual deficits may contribute to the heightened susceptibility of older individuals to severe outcomes following SARS‐CoV infection.
Yu‐Xuan Wu, Chih‐Wei Hu, Jui‐Yu Chang, Shuoh‐Wen Chen, Ting‐An Lin, Eric Chang‐Yi Lin, Min‐Hui Chen, Chuen‐Mi Yang, Hsuan‐Ying Lu, Ching‐Jung Teng, Yuan‐I Chang   +10 more
wiley   +1 more source

Human mastadenovirus pneumonia in two immunocompetent patients. [PDF]

Virol J
Hosch S, Hamelin B, Haslbauer JD, Field CM, Heim A, Boeck L, Savic Prince S, Gradistanac TA, Gander AE, Keller PM, Leuzinger K, Mertz KD.   +11 more
europepmc   +1 more source

Smoking Promotes AT2 Cell Senescence and Exacerbates Pulmonary Fibrosis by Downregulating POT1 via Integratively Inducing CpG Methylation and MECP2‐Mediated FOXP2 Transcriptional Binding Inhibition

Aging Cell, EarlyView.
Smoking is one of the major causes of pulmonary fibrosis (PF), and treatment options for PF are limited. We show that POT1 is decreased in PF patients and mice, especially in smoke exposure, and investigate its contributions to PF progression from protecting AT2 cell senescence to fibrosis. AAV9‐mediated restoration of POT1 prevents PF.
Mengkun Shi, Wei Wang, Posum Wan, Jialun Shi, Huixia Cui, Zhonghan Sun, Xiaofeng Chen, Jingyu Chen, Jiucun Wang, Xiangguang Shi   +9 more
wiley   +1 more source

Comparative study on the incidence of non-COVID-19 viral pneumonia before and after the COVID-19 pandemic: A retrospective analysis based on respiratory non-COVID viral nucleic acid results

Journal of Intensive Medicine
Background: The impact of the coronavirus disease 2019 (COVID-19) pandemic on the etiology of non-COVID-19 viral pneumonia remains to be identified. We investigated the evolution of non-COVID-19 viral pneumonia in hospitalized patients before and after ...
Xiaojiao Tan, Zheng Zhang, Huan Zhang, Jianbo Li, Xuewei Yang, Lijie Wang, Xuelian Liao   +6 more
doaj  

Comparison of Tomographic Findings in Patients with Influenza A (H1N1) and COVID-19. [PDF]

Diagnostics (Basel)
Vélez-Ramírez LN, Jiménez-Zarazúa O, González-Najera LE, Flores-Saldaña GA, Valdez-Escobedo A, Mondragón JD.   +5 more
europepmc   +1 more source