Results 121 to 130 of about 524,523 (149)

Divergent Total Syntheses of 7,20‐Epoxy, 3,20‐Epoxy, and 6,7‐seco‐ent‐Kaurane Diterpenoids

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
A concise and versatile synthesis of 7,20‐epoxy‐ent‐kaurane diterpenoids is developed and its tetracyclic core is converted divergently to the skeletons of 3,20‐epoxy and 6,7‐seco‐ent‐kaurane diterpenoids via a bioinspired strategy. Collectively nine total syntheses are achieved.
Bo Wang   +6 more
wiley   +1 more source

Practical management of repeated life‐threatening status epilepticus in Alternating Hemiplegia of Childhood: Case report and literature review

open access: yesEpileptic Disorders, EarlyView.
Abstract Background Alternating Hemiplegia of Childhood (AHC) is a severe channelopathy that manifests before 18 months of age, primarily caused by pathogenic variants in the ATP1A3 gene. It is characterized by recurrent and disabling episodes of plegia, dystonia, dysautonomia, along with chronic neurological features and cardiac arrhythmias. About 50%
Ramona Cordani   +8 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

open access: yesExploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang   +20 more
wiley   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

open access: yesExploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang   +4 more
wiley   +1 more source

Clinical value of dysregulated miR-125b-5p in severe pneumonia children. [PDF]

open access: yesBMC Immunol
Zhu M   +6 more
europepmc   +1 more source

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