Results 1 to 10 of about 1,648 (159)

Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis [PDF]

Diabetology and Metabolic Syndrome, 2021
Background Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. CircRNA polyribonucleotide nucleotidyltransferase 1 (circ-PNPT1) has been found to be abnormally expressed in GDM patients.
Li Zhang, Ming Zeng, Fei Tang, Jun Chen, Dongmei Cao, Ze-nan Tang   +5 more
exaly   +4 more sources

Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial homeostasis [PDF]

Molecular Metabolism
Objective: Metabolic-associated fatty liver disease (MAFLD) represents one of the most prevalent chronic liver conditions worldwide, but its precise pathogenesis remains unclear.
Guan Canghai
exaly   +4 more sources

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells [PDF]

Nature Communications
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano   +8 more
doaj   +7 more sources

Identification of genes potentially regulated by human polynucleotide phosphorylase (hPNPase old-35) using melanoma as a model. [PDF]

PLoS ONE, 2013
Human Polynucleotide Phosphorylase (hPNPase(old-35) or PNPT1) is an evolutionarily conserved 3'→ 5' exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and ...
Upneet K Sokhi, Manny D Bacolod, Santanu Dasgupta, Luni Emdad, Swadesh K Das, Catherine I Dumur, Michael F Miles, Devanand Sarkar, Paul B Fisher   +8 more
doaj   +3 more sources

Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis [PDF]

Nature Communications, 2023
Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where ...
Yujie Zhu, Mingchao Zhang, Weiran Wang, Shuang Qu, Minghui Liu, Weiwei Rong, Wenwen Yang, Hongwei Liang, Caihong Zeng, Xiaodong Zhu, Limin Li, Zhihong Liu, Ke Zen   +12 more
doaj   +2 more sources

A Novel Pathway of Functional microRNA Uptake and Mitochondria Delivery [PDF]

Advanced Science, 2023
Extracellular microRNAs (miRNAs) play a critical role in horizontal gene regulation. Uptake of extracellular miRNAs by recipient cells and their intracellular transport, however, remains elusive.
Jiachen Liu, Weili Li, Jianfeng Li, Eli Song, Hongwei Liang, Weiwei Rong, Xinli Jiang, Nuo Xu, Wei Wang, Shuang Qu, Shouyong Gu, Yujing Zhang, Chen‐ Yu Zhang, Ke Zen   +13 more
doaj   +2 more sources

Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance [PDF]

Cell Reports
Summary: Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including chemotherapy treatment.
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim, Mayur Sharma, Johnny Akers, Thien Nguyen, Eric Wong, Margot Martinez Moreno, Efrosini Kokkoli, Shobha Vasudevan, Sean E. Lawler, Wafik S. El-Deiry, Ziya Gokaslan, Clark C. Chen   +14 more
doaj   +2 more sources

Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury [PDF]

Frontiers in Aging Neuroscience
BackgroundOxidative stress is a pivotal mechanism implicated in the onset of traumatic brain injury (TBI), yet its precise role remains elusive. This study aims to elucidate the potential molecular interactions between key genes associated with oxidative
Bin Ren, Jifang Liang, Leifang Yang, Xiaocong Wei, Min Guo, Hong Li   +5 more
doaj   +2 more sources

Transcription, Maturation and Degradation of Mitochondrial RNA: Implications for Innate Immune Response [PDF]

Biomolecules
Mitochondria are crucial for a wide range of cellular processes. One of the most important is innate immunity regulation. Apart from functioning as a signaling hub in immune reactions, mitochondrial nucleic acids can themselves act as damage-associated ...
Chaojun Yan, Jianglong Yu, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Rui Zhang, Jingfeng Tang, Zhiyin Song, Cefan Zhou   +9 more
doaj   +2 more sources

Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness [PDF]

Frontiers in Genetics, 2018
Carotid intima-media thickness (cIMT) is an established heritable marker for subclinical atherosclerosis. In this study, we aim to identify rare variants with large effects driving differences in cIMT by performing genome-wide linkage analysis of ...
Dina Vojinovic, Maryam Kavousi, Mohsen Ghanbari, Mohsen Ghanbari, Rutger W. W. Brouwer, Jeroen G. J. van Rooij, Mirjam C. G. N. van den Hout, Robert Kraaij, Wilfred F. J. van Ijcken, Andre G. Uitterlinden, Andre G. Uitterlinden, Cornelia M. van Duijn, Cornelia M. van Duijn, Najaf Amin   +13 more
doaj   +7 more sources