Results 21 to 30 of about 704 (162)
URINARY NEPHRIN AS AN EARLY BIOMARKER OF HYPERTENSIVE NEPHROPATHY. [PDF]
Acta Clin Croat, 2023 Hypertensive nephropathy (HN) is characterized by kidney damage due to chronic high blood pressure. Podocytes play a crucial role in the pathogenesis of HN, thus, nephrin could be important in the early diagnosis of HN.
Kostovska I +3 more
europepmc +3 more sources
Early Renal Involvement in a Girl with Classic Fabry Disease [PDF]
Case Reports in Nephrology, Volume 2017, Issue 1, 2017., 2017 Fabry disease is an X-linked lysosomal storage disorder resulting from the deficiency or absence of the enzyme alpha galactosidase A; this defect leads to the systemic accumulation of globotriaosylceramide and its metabolites.
Fernando Perretta +2 more
core +3 more sources
Influence of Podocyte Injury on the Development of Class IV Lupus Nephritis [PDF]
International Journal of Nephrology and Renovascular DiseaseCyntia Camilo Franco Borges Zago,1 Bruna de Freitas Oliveira,1 Giovanna Uehara,1 Ana Laura Carvalho da Silva,1 Laura Penna Rocha,1 Fabiano Bichuette Custódio,2 Liliane Silvano Araújo,1 Crislaine Aparecida da Silva,1 Marlene Antônia Reis,1 Juliana Reis ...
Zago CCFB +9 more
doaj +2 more sources
Podocyturia as a Diagnostic Marker for Preeclampsia amongst High-Risk Pregnant Patients [PDF]
Journal of Pregnancy, 2012 Urinary podocyte (podocyturia) has been studied as a diagnostic marker for preeclampsia. We sought to validate its use in preeclampsia and in differentiating it from other high risk pregnancy states.
Belinda Jim +7 more
doaj +3 more sources
Podocyturia in Fabry disease: a 10-year follow-up. [PDF]
Clin Kidney J, 2022 AbstractBackgroundFabry disease (FD) is a rare X-linked disorder of sphingolipid metabolism that results in chronic proteinuric nephropathy. Podocytes are one of the most affected renal cells and play an important role in the development and progression of kidney disease.
Vujkovac B +5 more
europepmc +4 more sources
An expert consensus on the recommendations for the use of biomarkers in Fabry disease [PDF]
, 2023 Fabry disease is an X-linked lysosomal storage disorder caused by the accumulation of glycosphingolipids in various tissues and body fluids, leading to progressive organ damage and life-threatening complications.
Spada, Marco
core +10 more sources
Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy. [PDF]
PLoS ONE, 2016 Chronic kidney disease is a major complication of Fabry disease. Podocytes accumulate globotriaosylceramide inclusions more than other kidney cell types in Fabry patients. Podocyte injury occurs early in age, and is progressive.
Brent Fall +8 more
doaj +1 more source
Molecules, 2021 Early detection of any preeclampsia biomarkers may lower the risk of mortality, both for a mother and a child. Our study focuses on techniques for preeclampsia biomarker identification by comparing the results of a method using liquid chromatography mass
Paulina Grocholska +8 more
doaj +1 more source
CMIP interacts with WT1 and targets it on the proteasome degradation pathway
Clinical and Translational Medicine, Volume 11, Issue 7, July 2021., 2021 INS patients show increased CMIP and decreased WT1 expression in podocytes. CMIP inhibits NF‐κB‐driven WT1 transcription in M15 cells. CMIP targets WT1 to proteasome degradation via ubiquitin ligase activity in M15 cells. RNAi against Cmip restores Wt1 expression in a mouse model of proteinuria.
Shao‐Yu Zhang +8 more
wiley +1 more source
Jornal Brasileiro de Nefrologia, 2016 Fabry disease is a lysosomal storage disorder due to abnormalities in the GLA gene (Xq22). Such changes result in the reduction/absence of activity of the lysosome enzyme α-GAL, whose function is to metabolize globotriaosylceramide (Gb3). Renal disease is a major clinical outcome of the accumulation of Gb3.
Ester Miranda, Pereira +4 more
openaire +3 more sources