Results 111 to 120 of about 19,338 (290)

Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study

Journal of Oral Biology and Craniofacial Research, 2016
Background: The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles ...
Sindhu M. Ganvir, Pratima G. Khobragade, Swati A. Bamane, Ramnivas Kumavat, Amit Dalmia   +4 more
doaj   +1 more source

Podoplanin: An emerging cancer biomarker and therapeutic target

Cancer Science, 2018
Podoplanin (PDPN) is a transmembrane receptor glycoprotein that is upregulated on transformed cells, cancer associated fibroblasts and inflammatory macrophages that contribute to cancer progression.
Harini Krishnan, Julie Rayes, T. Miyashita, G. Ishii, Edward P. Retzbach, Stephanie A. Sheehan, Ai Takemoto, Yao-Wen Chang, K. Yoneda, J. Asai, L. Jensen, Lushun Chalise, A. Natsume, G. Goldberg   +13 more
semanticscholar   +1 more source

Lymphangiogenesis: from the pig embryos to cancer [PDF]

, 2008
The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic system during the development of medical science.
Duarte, Maria, Longatto Filho, Adhemar, Schmitt, Fernando C.   +2 more
core   +3 more sources

The Role of Podoplanin in the Biology of Differentiated Thyroid Cancers [PDF]

PLoS ONE, 2014
Podoplanin (PDPN), a mucin-type transmembrane glycoprotein specific to the lymphatic system is expressed in a variety of human cancers, and is regarded as a factor promoting tumor progression. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells.
Tomasz Stępień, Justyna Sikorska, Magdalena Rudzińska, Damian Gawel, Mirosław Kiedrowski, Barbara Czarnocka, Kamila Karpińska, Magdalena Marchlewska   +7 more
openaire   +6 more sources

Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objectives To assess the available evidence on the expression of hallmarks of cancer and oral leukoplakia (OL) malignant transformation probability, with the goal of identifying the earliest oncogenic molecular events participating in oral cancer carcinogenesis.
I. González‐Ruiz, P. Ramos‐García, H. Boujemaoui‐Boulaghmoudi, N. Mjouel‐Boutaleb, M. A. González‐Moles   +4 more
wiley   +1 more source

Elucidating the Anticancer Mechanisms of Tetrahydroxycurcumin: A Comprehensive Review of Preclinical Studies

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Tetrahydroxycurcumin is an attractive multifunctional compound in cancer‐driven therapeutics. Its anticancer potential in modulating a wide range of oncogenic signaling networks, combined with its dual properties as an antioxidant and anti‐inflammatory agent, highlights its potential to become a transformative anticancer drug.
Muhammad Shahbaz, Ushna Momal, Hagar M. Mohamed, Asfa Perween, Hammad Naeem, Muhammad Imran, Muzzamal Hussain, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Tadesse Fenta Yehuala, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Ehab M. Mostafa, Samy Selim   +14 more
wiley   +1 more source

Human Podoplanin-positive Monocytes and Platelets Enhance Lymphangiogenesis Through the Activation of the Podoplanin/CLEC-2 Axis [PDF]

Molecular Therapy, 2014
Emerging studies suggested that murine podoplanin-positive monocytes (PPMs) are involved in lymphangiogenesis. The goal of this study was to demonstrate the therapeutic lymphangiogenesis of human PPMs by the interaction with platelets. Aggregation culture of human peripheral blood mononuclear cells (PBMCs) resulted in cellular aggregates termed ...
Ji Yeon Yun, Jae Hee Jang, Seung Bum Ko, Jin Hur, Il Young Oh, Il Young Oh, Young Bae Park, Hyo-Soo Kim, Jae Il Choi, Jin A. Kang, Jeehoon Kang, Joonoh Kim, Young Eun Choi, Sang Eun Lee, Hwan Lee   +14 more
openaire   +3 more sources

The structure of CLEC-2: mechanisms of dimerization and higher-order clustering

Platelets, 2021
The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent.
Eleyna M Martin, Malou Zuidscherwoude, Luis a Morán, Ying Di, Angel García, Steve P Watson   +5 more
doaj   +1 more source

Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function.

JCI Insight, 2020
Multiple organ failure in sepsis is a progressive failure of several interdependent organ systems. Liver dysfunction occurs early during sepsis and is directly associated with patient death; however, the underlying mechanism of liver dysfunction is ...
Zhanli Xie, Bojing Shao, Christopher M Hoover, M. McDaniel, Jian-hua Song, M. Jiang, Zhen-ni Ma, Fei Yang, Jingjing Han, X. Bai, C. Ruan, Lijun Xia   +11 more
semanticscholar   +1 more source

Two Sides of the Same Coin—Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Extracellular vesicles (EVs) have gained increasing attention in recent years due to their pivotal role in both health and disease. Emerging from both eukaryotic and prokaryotic cells, EVs serve as essential mediators of intercellular communication, exceeding the simplistic interactions observed with individual molecules. In this comprehensive
Philipp Arnold, Fanni Annamária Boros, Jochen Mattner, Gerald Seidel, Chaofan Liu, Inga Viktoria Hensel, Jan Van Deun, Raphael Schwendner, Janina Müller‐Deile, Nina Sopel, Andreas Ramming, Mario R. Angeli, Simon Rauber, Cláudia Vilhena, Andreas Baur, Stefan Wirtz, Klaus Überla, Heiko Reutter, Linda‐Marie Mulzer, Alina C. Hilger, Friederike Zunke, Wei Xiang, Gregor Fuhrmann, Claudia Günther   +23 more
wiley   +1 more source