Results 91 to 100 of about 11,070 (170)

Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells

, 2013
Podoplanin, a mucin-like plasma membrane protein, is expressed by lymphatic endothelial cells and responsible for separation of blood and lymphatic circulation through activation of platelets.
Bauer, Miroslav, Sixt, Michael K ; https://orcid.org/, Gerhard J. Schütz, Raab, Ingrid, Schachner, Helga, Jan Zaujec, Dontscho Kerjaschki, Weber, Michele, Kerjaschki, Dontscho, Bernd R. Binder, Hannes Stockinger, Schütz, Gerhard, Pavel Uhrin, Uhrin, Pavel, Binder, Bernd R., Michael Sixt, Elke Fuertbauer, Stockinger, Hannes, Michele Weber, Sixt, Michael, Schütz, Gerhard J., Ingrid Raab, Helga Schachner, Zaujec, Jan, Binder, Bernd, Miroslav Bauer, Fuertbauer, Elke   +26 more
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Examples of the "organized" pattern of podoplanin in EPS.

, 2012
Peritoneal biopsies from patients with EPS were stained with monoclonal antibodies against podoplanin (A, C, E). Consecutive section stained with monoclonal antibody against SMA (B, D, F) showed that many cells appeared to express both proteins.
Seth L. Alper (107061), Peter Fritz (59203), Fabian Reimold (107060), Clemens D. Cohen (107065), M. Dominik Alscher (107057), Niko Braun (107056), Stephan Segerer (88027), Dagmar Biegger (107063), Maja Lindenmeyer (107064), Rudolf P. Wüthrich (103623), Joerg Latus (107058), Martin Kimmel (107062), Ilka Edenhofer (107059)   +12 more
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Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma

JTO Clinical and Research Reports
Introduction: Resistance to EGFR tyrosine kinase inhibitors is influenced by tumor-intrinsic and -extrinsic factors. We investigated the impact of tumor cell histology and tumor microenvironment on the efficacy of osimertinib.
Yuji Uehara, MD, Hiroki Izumi, MD, PhD, Tetsuro Taki, MD, PhD, Tetsuya Sakai, MD, PhD, Hibiki Udagawa, MD, PhD, Eri Sugiyama, MD, PhD, Shigeki Umemura, MD, PhD, Yoshitaka Zenke, MD, PhD, Shingo Matsumoto, MD, PhD, Kiyotaka Yoh, MD, PhD, Shoko Kubota, MD, PhD, Keiju Aokage, MD, PhD, Naoya Sakamoto, MD, PhD, Shingo Sakashita, MD, PhD, Motohiro Kojima, MD, PhD, Michiko Nagamine, MD, PhD, Yukio Hosomi, MD, PhD, Masahiro Tsuboi, MD, PhD, Koichi Goto, MD, PhD, Genichiro Ishii, MD, PhD   +19 more
doaj   +1 more source

Platelet CLEC-2 and podoplanin in cancer metastasis

, 2012
It has long been recognised that the function of platelets in health and disease span far beyond their roles in haemostasis and thrombosis. The observation that tumour cells induce platelet aggregation was followed by extensive experimental evidence ...
Lowe, Kate L, Watson, Steve; id_orcid, Navarro Nunez, Leyre, Watson, Stephen P   +3 more
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Podoplanin expression in adamantinoma of long bones and osteofibrous dysplasia

, 2011
Adamantinoma of long bones (ALB) and osteofibrous dysplasia (OFD) are rare osteolytic bone tumours that principally arise in the tibia. Both ALB and OFD contain epithelial and stromal elements, as well as areas of fibro-osseous proliferation. We assessed
Flanagan, AM, Dongre, A, Dongre, A., Taylor, R., Taylor, R, Athanasou, Nicholas, Hogendoorn, PCW, Athanasou, NA, Athanasou, N.A., Kashima, T.G., Hogendoorn, P.C.W., Flanagan, A.M., Kashima, TG   +12 more
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Immunohistochemical staining with palladin, podoplanin, and α-SMA antibodies.

, 2016
A-C were from the same core and stained with palladin (A, ×100), α-SMA (B, ×100), and podoplanin (C, ×100). These were regarded as positive. D: Few palladin-stained stromal cells are seen, but the proportion is
Takahiro Tsuchikawa (3214812), Yutaka Hatanaka (3214818), Asami Morooka (3214821), Satoshi Hirano (443831), Katsuji Marukawa (3214815), Tomoko Mitsuhashi (5318), Yoshihiro Matsuno (22044), Daisuke Sato (504226), Toshiaki Shichinohe (3214824), Toru Nakamura (9142)   +9 more
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Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma

Frontiers in Immunology
IntroductionMelanoma is a highly immunogenic and aggressive malignancy characterized by pronounced intratumoral lymphocytic infiltration and significant responsiveness to immunotherapeutic interventions.
Chunyan Feng, Yueyue Liu, Xinyue Zhong, Zhenzhen Wei, Hongjing Cui, Jianfeng Yi   +5 more
doaj   +1 more source

The quantitative mRNA detection of podoplanin in body cavity fluids [PDF]

, 2006
OBJECTIVE: The aim of this study was to evaluate whether podoplanin mRNA expression in body cavity fluids can be used as an adjunctive tool for cytological diagnosis.METHODS: Twenty‐two body cavity fluids, including 9 pleural fluids, 11 ascitic fluids, 1
ヤマヌシ, トモコ, 山主, 智子, 塩岡, 忠夫, 山本, 康子, 大崎, 博之, ヤマモト, ヤスコ, Nakano, Masayuki, Yamanushi, Tomoko, 中野, 正行, Yamamoto, Yasuko, 秦, 幸吉, Hata, Kohkichi, シオオカ, タダオ, Shiooka, Tadao, ヒラカワ, エイイチロウ, ナカノ, マサユキ, Ohsaki, Hiroyuki, オオサキ, ヒロユキ, ハタ, コウキチ, Hirakawa, Eiichiro, 平川, 栄一郎   +20 more
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Podoplanin Expression in Early-Stage Colorectal Cancer-Associated Fibroblasts and Its Utility as a Diagnostic Marker for Colorectal Lesions

Cells
(Background) Cancer-associated fibroblasts (CAFs) are major cancer stromal components. CAFs have diverse functions and cell origins. Podoplanin (PDPN), a lymphatic vessel marker, is also a CAF marker in certain cancers.
Shuichi Tsukamoto, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Tomoo Itoh, Hiroshi Yokozaki, Yu-ichiro Koma   +6 more
doaj   +1 more source

Stromal podoplanin expression and its clinicopathological role in breast carcinoma

, 2018
Introduction: Breast cancer is still a serious health problem in 21st century and diagnosis, treatment and prognosis of this malignant disease are subject to many research.
Mohd Nazirul Mubin bin Puteh Ahmad
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