Results 71 to 80 of about 11,879 (214)

Expression of podoplanin in oral premalignant and malignant lesions and its potential as a biomarker

Indian Journal of Dental Research, 2014
Aim: To analyze and compare the expression of podoplanin in normal oral tissues, leukoplakia and oral squamous cell carcinoma (OSCC) and to predict its use as a biomarker. Materials and Methods: Ninety-two formalin fixed paraffin embedded tissue samples
J Logeswari, N Malathi, H Thamizhchelvan, N Sangeetha, S Vijaya Nirmala   +4 more
doaj   +1 more source

Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis

Cells, 2020
Podoplanin is a small transmembrane mucin-like glycoprotein that plays a crucial role in the development of the lung, heart and lymphatic vascular system.
Marko Sesartić, Kristian Ikenberg, Sun-Young Yoon, Michael Detmar   +3 more
doaj   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Morphological study of tooth development in podoplanin-deficient mice. [PDF]

, 2018
福岡歯科大学博士（歯学）2017年度Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes ...
Oka, Kyoko, Kato, Yukinari, Maruo, Naoki, Takara, Kenyo, Hatakeyama, Yuji, Yamashita, Junro, Kaji, Chiaki, Sawa, Yoshihiko, Sawa, Naruhiko, Kojima, Hiroshi   +9 more
core  

Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment

Biology of the Cell, Volume 118, Issue 10, October 2026.
Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier, Apolline Salama, Laurence Dubreil, Grégoire Mignot, Steffi Bosch   +4 more
wiley   +1 more source

Detection of lymphangiogenesis in non-small cell lung cancer and its prognostic value

Journal of Experimental & Clinical Cancer Research, 2009
Background Our aim was to detect lymphatic endothelial marker podoplanin, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and vascular endothelial growth factor receptor-3 (VEGFR)-3 and study the prognostic relevance of lymphangiogenesis in ...
Liao Rong-xia, Zhu Bo, Zhuo Wen-lei, Chen Zheng-tang, Wang Yan, Sun Jian-guo, Zhang Shao-xiang   +6 more
doaj   +1 more source

The structure of CLEC-2: mechanisms of dimerization and higher-order clustering

Platelets, 2021
The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent.
Eleyna M Martin, Malou Zuidscherwoude, Luis a Morán, Ying Di, Angel García, Steve P Watson   +5 more
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 54, 28 September 2026.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis [PDF]

, 2017
Platelets play a critical role in vascular inflammation through the podoplanin and collagen/fibrin receptors, C-type-lectin-like-2 (CLEC-2) and glycoprotein VI (GPVI), respectively.
Di, Ying, Kassiani Skordilis, Ying Di, Stephanie Lombard, Watson, Stephanie, Stuart W. Smith, Smith, Stuart, Siân Lax, Rayes, Julie, Stephanie K. Watson, Surasak Wichaiyo, Skordilis, Kassiani, Beata Grygielska, Watson, Steve; id_orcid, Wichaiyo, Surasak, Julie Rayes, Lombard, Stephanie, Lax, Sian; id_orcid, Grygielska, Beata, Steve P. Watson   +19 more
core   +1 more source

CLEC-2 and podoplanin, partners again [PDF]

Blood, 2016
In this issue of Blood, Tamura et al reveal a novel function for podoplanin on periarteriolar stromal cells in the bone marrow: promoting megakaryocyte growth and proplatelet formation by interaction with C-type lectin-like receptor 2 (CLEC-2).
Jianxin Fu, Lijun Xia
openaire   +2 more sources