Results 71 to 80 of about 11,070 (170)

Detection of lymphangiogenesis in non-small cell lung cancer and its prognostic value

Journal of Experimental & Clinical Cancer Research, 2009
Background Our aim was to detect lymphatic endothelial marker podoplanin, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and vascular endothelial growth factor receptor-3 (VEGFR)-3 and study the prognostic relevance of lymphangiogenesis in ...
Liao Rong-xia, Zhu Bo, Zhuo Wen-lei, Chen Zheng-tang, Wang Yan, Sun Jian-guo, Zhang Shao-xiang   +6 more
doaj   +1 more source

Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Using cyclic multiplex microscopy in an IL‐33‐driven type 2 inflammation model, we validated a spatial workflow mapping rare lung ILCs. High‐dimensional analysis revealed a conserved peri‐lymphatic niche at early time points of inflammation where ILC2s and myeloid cells co‐localize with LYVE1+ vessels, highlighting a structured immunological ...
Sandy Kroh, Anna Pascual‐Reguant, Artür Manukyan, Ralf Uecker, Robert Günther, Lars Philipsen, Ralf Koehler, Peggy Mex, Markus Landthaler, Raluca A. Niesner, Anja E. Hauser   +10 more
wiley   +1 more source

Clinical Interpretation of Platelet Activation Marker sCLEC‐2 in Antiphospholipid Syndrome

Journal of Clinical Laboratory Analysis, Volume 40, Issue 10, May 2026.
Soluble C‐type lectin‐like receptor 2 (sCLEC‐2), a marker of platelet activation, was evaluated in patients with antiphospholipid syndrome (APS). Plasma sCLEC‐2 levels and the sCLEC‐2/D‐dimer ratio were significantly elevated in APS compared with other collagen diseases and healthy controls.
Risa Kaneshige, Yukari Motoki, Kiyoshi Ichihara, Junzo Nojima   +3 more
wiley   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction.

PLoS ONE, 2019
Podoplanin, a transmembrane glycoprotein, is overexpressed in certain types of tumors and induces platelet aggregation by binding to C-type lectin-like receptor 2 (CLEC-2) on the platelet membrane. Activated platelets release granule components, which in
Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi   +10 more
doaj   +1 more source

Podoplanin mRNA levels are increased in EPS.

, 2012
RNA samples from patients on PD without signs of EPS (n = 5), and with EPS (n = 5), as well as control biopsies from patients with uremia (n = 5) and normal peritoneum taken during laparatomy (n = 5).
Seth L. Alper (107061), Peter Fritz (59203), Fabian Reimold (107060), Clemens D. Cohen (107065), M. Dominik Alscher (107057), Niko Braun (107056), Stephan Segerer (88027), Dagmar Biegger (107063), Maja Lindenmeyer (107064), Rudolf P. Wüthrich (103623), Joerg Latus (107058), Martin Kimmel (107062), Ilka Edenhofer (107059)   +12 more
core   +1 more source

Comparing Immunohistochemical Expression of Podoplanin between Oral Squamous Cell Carcinoma and Normal Oral Mucosa

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. Podoplanin is a mucin-like integral membrane glycoprotein that is expressed in the lymphatic endothelial cells but not in the blood vascular ...
Samareh Jazayeri, Maryam Seyedmajidi, Fatima Bijani, Seyedali Seyedmajidi   +3 more
doaj  

The role of podoplanin in cutaneous wound healing

, 2011
Die vorliegende Arbeit befasst sich mit der Funktion welche Podoplanin, ein 43kDa mucin-artiges transmembranes Sialoglycoprotein während der kutanen Wundheilung erfüllt.
Koban, Florian
core  

Ekspresja genu podoplaniny w złośliwych nowotworach jajnika

Menopause Review, 2011
Introduction: Ovarian cancer is mostly diagnosed in postmenopausal women. The hormonal microenvironmentof ovarian tumour development in pre- and postmenopausal women is different.
Janusz Kocki, Halina Antosz, Marek Cybulski, Józef Kotarski, Barbara Marzec-Kotarska, Wiesława Bednarek   +5 more
doaj  

Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets. [PDF]

, 2019
Mesenchymal stromal cells (MSCs) upregulate podoplanin at sites of infection, chronic inflammation and cancer. Here, we investigated the functional consequences of podoplanin expression on the migratory potential of MSCs and their interactions with ...
Marshall, Jennifer L; id_orcid, Nash, Gerard B, Sheriff, Lozan, Manning, Julia E, McGettrick, Helen M; id_orcid, Brill, Alexander, Ward, Lewis S C   +6 more
core   +1 more source