Results 51 to 60 of about 11,879 (214)

Risking thromboembolism: podoplanin and glioma [PDF]

Blood, 2017
In this issue of Blood , [Riedl et al][1] evaluate the link between tumor podoplanin expression and the prothrombotic state inherent to glioma and find that podoplanin expression is associated with altered markers of coagulation activation and an increased risk of venous thromboembolism.[1][2] ![
openaire   +2 more sources

Podoplanin is a negative regulator of Th17 inflammation [PDF]

JCI Insight, 2017
Recent data indicate that there are different subpopulations of Th17 cells that can express a regulatory as opposed to an inflammatory gene signature. The transmembrane glycoprotein PDPN is critical in the development of multiple organs including the lymphatic system and has been described on T cells in mouse models of autoimmune ...
Alyssa N, Nylander, Gerald D, Ponath, Pierre-Paul, Axisa, Mayyan, Mubarak, Mary, Tomayko, Vijay K, Kuchroo, David, Pitt, David A, Hafler   +7 more
openaire   +2 more sources

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Podoplanin is a useful prognostic marker and indicates better differentiation in lung squamous cell cancer patients? A systematic review and meta-analysis

BMC Cancer, 2020
Background The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis among squamous cancers.
Liya Hu, Peng Zhang, Qi Mei, Wei Sun, Lei Zhou, Tiejun Yin   +5 more
doaj   +1 more source

Corneal transplantation: Restoring sight to the blind

Acta Ophthalmologica, EarlyView.
Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley   +1 more source

Adding Intratumoral Antibody‐Photoabsorber Conjugate Improves Efficacy of Near‐Infrared Photoimmunotherapy (NIR‐PIT)

Cancer Science, EarlyView.
Intravenous (IV) or intratumoral (IT) cetuximab distribution in A431 tumor (essence of Figure 2). ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in ...
Miyu Kano, Aki Furusawa, Seiichiro Takao, Makoto Kano, Motofumi Suzuki, Hiroshi Yamamoto, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi   +9 more
wiley   +1 more source

Evaluation of Podoplanin in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Scientifica, 2015
Background. Recent studies have demonstrated that podoplanin was expressed in some dysplastic lesions adjacent to primary oral cancers suggesting that podoplanin expression may occur in early oral tumorigenesis and lymphangiogenesis and therefore is ...
Ashok Patil, Kishor Patil, Suyog Tupsakhare, Mahesh Gabhane, Shrikant Sonune, Shilpa Kandalgaonkar   +5 more
doaj   +1 more source

Extracellular Matrix Remodeling in Actinic Cheilitis and Lip Squamous Cell Carcinoma: A Cross‐Sectional Study

Oral Diseases, EarlyView.
ABSTRACT Background Actinic cheilitis is a precursor to lip squamous cell carcinoma. How ultraviolet‐induced stromal degeneration relates to invasion‐related extracellular matrix markers remains unclear. This study investigated basophilic degeneration of collagen, solar elastosis, fibronectin, tenascin‐C, and podoplanin in both lesions.
Caroline Alfaia‐Silva, Polyane Caroline Arruda de Farias, Fernanda de Mello da Silva, Lidiane de Paula Ribeiro, Ericles de Paiva Vieira, Elena Riet Correa Rivero, Filipe Modolo   +6 more
wiley   +1 more source

Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study

Journal of Applied Oral Science
SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis.
Sonali Pradhan, Vasudeva Guddattu, Monica Charlotte Solomon   +2 more
doaj   +1 more source

Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma

Molecular Therapy: Oncolytics, 2022
Glioblastoma is a devastating malignant brain tumor with a poor prognosis despite standard therapy. Podoplanin (PDPN), a type I transmembrane mucin-like glycoprotein that is overexpressed in various cancers, is a potential therapeutic target for the ...
Lushun Chalise, Akira Kato, Masasuke Ohno, Sachi Maeda, Akane Yamamichi, Shunichiro Kuramitsu, Satoshi Shiina, Hiromi Takahashi, Sachiko Ozone, Junya Yamaguchi, Yukinari Kato, Yumi Rockenbach, Atsushi Natsume, Tomoki Todo   +13 more
doaj   +1 more source