Results 51 to 60 of about 11,070 (170)

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis [PDF]

, 2017
Platelets play a critical role in vascular inflammation through the podoplanin and collagen/fibrin receptors, C-type-lectin-like-2 (CLEC-2) and glycoprotein VI (GPVI), respectively.
Di, Ying, Kassiani Skordilis, Ying Di, Stephanie Lombard, Watson, Stephanie, Stuart W. Smith, Smith, Stuart, Siân Lax, Rayes, Julie, Stephanie K. Watson, Surasak Wichaiyo, Skordilis, Kassiani, Beata Grygielska, Watson, Steve; id_orcid, Wichaiyo, Surasak, Julie Rayes, Lombard, Stephanie, Lax, Sian; id_orcid, Grygielska, Beata, Steve P. Watson   +19 more
core   +1 more source

Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study

Journal of Applied Oral Science
SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis.
Sonali Pradhan, Vasudeva Guddattu, Monica Charlotte Solomon   +2 more
doaj   +1 more source

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

Retrovirology, 2010
Background Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream.
Münch Jan, Schmökel Jan, Kato Yukinari, Glowacka Ilona, Bertram Stephanie, Tsegaye Theodros, Steffen Imke, Chaipan Chawaree, Simmons Graham, Gerardy-Schahn Rita, Pöhlmann Stefan   +10 more
doaj   +1 more source

Novel Combination of Surface Markers for the Reliable and Comprehensive Identification of Human Thymic Epithelial Cells by Flow Cytometry: Quantitation and Transcriptional Characterization of Thymic Stroma in a Pediatric Cohort

Frontiers in Immunology, 2021
Thymic epithelial cells (TECs) are essential in supporting the development of mature T cells from hematopoietic progenitor cells and facilitate their lineage-commitment, proliferation, T-cell receptor repertoire selection and maturation.
Veronika Haunerdinger, Maria Domenica Moccia, Lennart Opitz, Stefano Vavassori, Hitendu Dave, Mathias M. Hauri-Hohl   +5 more
doaj   +1 more source

Diagnostic yield of OCT3/4 reflex testing in testicular biopsy

Histopathology, Volume 89, Issue 1, Page 136-143, July 2026.
GCNIS detection frequency was 48/3353 (1.4%) testicular biopsies from 42/1870 (2.2%) men who underwent testicular biopsy with or without testicular sperm extraction (TESE). OCT3/4 was particularly helpful for detecting interstitial seminoma, GCNIS coexisting with mature spermatogenesis, and focal GCNIS.
Roselyne Choiniere, Willem PA Boellaard, Geert JLH van Leenders   +2 more
wiley   +1 more source

Is podoplanin expression associated with the proliferative activity of ameloblastomas?

, 2012
Oral Diseases (2012) 18, 673679 Objectives: The aim of this study was to investigate the relationship between podoplanin expression and proliferative activity of ameloblastomas and remnants of the odontogenic epithelium from dental follicles (DF) of ...
Lauris, J. R. P., Oliveira, D. T., Soares, C. T., Damante, J. H., Tjioe, K. C.   +4 more
core   +1 more source

Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study

Journal of Oral Biology and Craniofacial Research, 2016
Background: The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles ...
Sindhu M. Ganvir, Pratima G. Khobragade, Swati A. Bamane, Ramnivas Kumavat, Amit Dalmia   +4 more
doaj   +1 more source

CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis

Frontiers in Immunology, 2021
Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood.
Joshua H. Bourne, Nonantzin Beristain-Covarrubias, Malou Zuidscherwoude, Malou Zuidscherwoude, Joana Campos, Ying Di, Evelyn Garlick, Evelyn Garlick, Martina Colicchia, Lauren V. Terry, Steven G. Thomas, Steven G. Thomas, Alexander Brill, Alexander Brill, Jagadeesh Bayry, Jagadeesh Bayry, Steve P. Watson, Steve P. Watson, Julie Rayes, Julie Rayes   +19 more
doaj   +1 more source

ZEB1 Modifies VE‐Cadherin Signaling in Lymphatic Endothelial Cells

Microcirculation, Volume 33, Issue 5, July 2026.
ABSTRACT Objective Zinc finger E‐box‐binding homeobox 1 (ZEB1) is a transcription factor primarily known for its regulatory roles in epithelial‐to‐mesenchymal transition (EMT) and cell fate determination. Recent studies suggest that endothelial ZEB1 signaling promotes blood vessel growth and reduces junctional integrity, although the underlying ...
Nada S. Ahmed, Joseph L. Horder, Charles T. Cresswell, Poppy E. Harris, Amy P. Lynch, Zarah B. Tabrizi, Kathryn R. Green, James H. Hallwood, Anton C. Smith, Michael A. Portelli, Alexander J. Fezovich, Christos Spanos, David S. Gardner, Alan McIntyre, Sarah J. Storr, Daniel G. Booth, David O. Bates, Andrew V. Benest   +17 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source