Results 31 to 40 of about 11,879 (214)

Podoplanin: Its roles and functions in neurological diseases and brain cancers

Frontiers in Pharmacology, 2022
Podoplanin is a small mucin-like glycoprotein involved in several physiological and pathological processes in the brain including development, angiogenesis, tumors, ischemic stroke and other neurological disorders. Podoplanin expression is upregulated in
Yi Wang, Dan Peng, Yaqian Huang, Yongjun Cao, Hui Li, Xia Zhang   +5 more
doaj   +1 more source

Podoplanin [PDF]

Journal of Neuropathology & Experimental Neurology, 2015
Reactive astrogliosis is associated with many pathologic processes in the central nervous system, including gliomas. The glycoprotein podoplanin (PDPN) is upregulated in malignant gliomas. Using a syngeneic intracranial glioma mouse model, we show that PDPN is highly expressed in a subset of glial fibrillary acidic protein-positive astrocytes within ...
Kushal, Kolar, Moises, Freitas-Andrade, John F, Bechberger, Harini, Krishnan, Gary S, Goldberg, Christian C, Naus, Wun Chey, Sin   +6 more
openaire   +2 more sources

Podoplanin Expression in Canine Melanoma [PDF]

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2016
A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein,
Satoshi, Ogasawara, Ryusuke, Honma, Mika K, Kaneko, Yuki, Fujii, Yumiko, Kagawa, Satoru, Konnai, Yukinari, Kato   +6 more
openaire   +2 more sources

Thr80 of Sheep Podoplanin Is a Critical Epitope of the Antisheep Podoplanin Monoclonal Antibody: PMab-256 [PDF]

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2020
An antisheep podoplanin (sPDPN) monoclonal antibody (mAb), PMab-256, has recently been established. PMab-256 shows positive immunostaining for lymphatic endothelial cells, lung type I alveolar cells, and kidney podocytes. PDPN possesses three platelet-aggregation-stimulating (PLAG) domains, PLAG1, PLAG2, and PLAG3, and a PLAG-like domain (PLD).
Yukinari, Kato, Masato, Sano, Teizo, Asano, Yusuke, Sayama, Mika K, Kaneko   +4 more
openaire   +2 more sources

Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?

European Journal of Histochemistry, 2015
The association between podoplanin and ezrin in the process of odontogenic tumors invasion has been suggested, but was not studied yet. Our purpose was to investigate the relationship between podoplanin and ezrin expressions in the odontogenic epithelium
Y.F. Costa, K.C. Tjioe, S. Nonogaki, F.A. Soares, J.R. Pereira Lauris, D. Tostes Oliveira   +5 more
doaj   +1 more source

New trends in the study of podoplanin as a cell morphological regulator

Japanese Dental Science Review, 2010
Podoplanin is a mucin-type glycoprotein firstly identified in podocytes, which is homologous to the type I alveolar cell specific T1α-2 antigen and to the oncofetal antigen M2A recognized by the D2-40 antibody. Podoplanin possesses a platelet aggregation-
Yoshihiko Sawa
doaj   +1 more source

Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation

Scientific Reports, 2017
Podoplanin/Aggrus, known as a platelet aggregation-inducing factor, is frequently overexpressed in lung squamous cell carcinomas (LSCC) and glioblastomas among other tumours, and its expression has been reported to be correlated with poor prognosis ...
Kenichi Miyata, Ai Takemoto, Sakae Okumura, Makoto Nishio, Naoya Fujita   +4 more
doaj   +1 more source

Cancer - from mechanisms of invasion to targeted therapy [PDF]

, 2007
Cancer is one of the big challenges of modern medicine. The manifestations of cancer are manifold, and the knowledge of the etiology of cancer is still fragmentary. In order to understand the disease, the complete molecular apparatus and the whole signal
Wicki, Andreas Christian
core   +1 more source

Podoplanin increases the migration of human fibroblasts and affects the endothelial cell network formation: A possible role for cancer-associated fibroblasts in breast cancer progression.

PLoS ONE, 2017
In our previous studies we showed that in breast cancer podoplanin-positive cancer-associated fibroblasts correlated positively with tumor size, grade of malignancy, lymph node metastasis, lymphovascular invasion and poor patients' outcome.
Jaroslaw Suchanski, Anna Tejchman, Maciej Zacharski, Aleksandra Piotrowska, Jedrzej Grzegrzolka, Grzegorz Chodaczek, Katarzyna Nowinska, Janusz Rys, Piotr Dziegiel, Claudine Kieda, Maciej Ugorski   +10 more
doaj   +1 more source

Podoplanin as a predictive marker for identification of high-risk mycosis fungoides patients: An immunohistochemical study

Indian Journal of Dermatology, 2020
Background: Podoplanin, an important protein, has been implicated in various cellular processes, including lymphangiogenesis. Podoplanin is a mucin-type transmembrane glycoprotein that is accepted as a novel marker of lymphatic endothelial cells ...
Amal A El-Ashmawy, Maha M Shamloula, Nashwa N Elfar   +2 more
doaj   +1 more source