Results 21 to 30 of about 11,879 (214)

Podoplanin immunopositive lymphatic vessels at the implant interface in a rat model of osteoporotic fractures [PDF]

, 2013
Insertion of bone substitution materials accelerates healing of osteoporotic fractures. Biodegradable materials are preferred for application in osteoporotic patients to avoid a second surgery for implant replacement. Degraded implant fragments are often
Vivien Kauschke, Hartmann, Sonja, Alexander Langheinrich, Matthias Schumacher, Matthias Schnabelrauch, Hanke, Thomas, Heiss, Christian, Olaf Kilian, Kauschke, Vivien, Sonja Hartmann, Christian Heiss, Alt, Volker, Heinemann, Sascha, Marian Kampschulte, Kilian, Olaf, Thormann, Ulrich, Lips, Katrin Susanne, Langheinrich, Alexander, Schumacher, Matthias, Michael Gelinsky, Armin R Kautz, Seemun Ray, Volker Alt, Kautz, Armin R, Kampschulte, Marian, Katrin Susanne Lips, Gelinsky, Michael, Ray, Seemun, Schnettler, Reinhard, Sascha Heinemann, Reinhard Schnettler, Ulrich Thormann, Schnabelrauch, Matthias, Kautz, Armin R., Thomas Hanke   +34 more
core   +1 more source

Immunohistochemical study of vascular endothelial growth factor‑C/vascular endothelial growth factor receptor‑3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis [PDF]

, 2015
The aim of the present study was to elucidate the associations between the expression of the vascular endothelial growth factor-C (VEGF-C)/VEGF receptor-3 (VEGFR-3) axis and lymphangiogenesis, regional lymph node metastasis and clinicopathological ...
Asahina, Izumi, Takahashi, Hidenori, Shiraishi, Takeshi, Umeda, Masahiro, Yanamoto, Souichi, Yamada, Shin-Ichi, Matsushita, Yuki, Imayama, Naomi, Naruse, Tomofumi, Yamada, Shin‑Ichi, Ikeda, Hisazumi, Fujita, Shuichi, Ikeda, Tohru   +12 more
core   +1 more source

Detection of Lion Podoplanin Using the Antitiger Podoplanin Monoclonal Antibody PMab-231 [PDF]

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2020
Monoclonal antibodies (mAbs) that specifically target podoplanin (PDPN), a marker for type I alveolar cells, are needed for immunohistochemical analyses. Anti-PDPN mAbs are available for many species, including human, mouse, rat, rabbit, dog, cat, bovine, pig, Tasmanian devil, alpaca, tiger, whale, goat, horse, bear, and sheep ...
Yukinari, Kato, Junko, Takei, Masato, Sano, Teizo, Asano, Yusuke, Sayama, Kazuyuki, Uchida, Takayuki, Nakagawa, Mika K, Kaneko   +7 more
openaire   +2 more sources

The role of podoplanin inhibitors in controlling oral cancer progression [PDF]

, 2023
Objective: In this article, we review the current studies on the role of podoplanin in oral cancer and the potential application of podoplanin inhibitors as a therapeutic agent for oral cancer.
Engku Ngah Sayuddin, Engku Nasiha, Rostam, Muhamad Ashraf, Burhanudin, Nor Aszlitah, Arzmi, Mohd Hafiz, Bakhtiar, Muhammad Taher   +4 more
core   +1 more source

Targeting Podoplanin for the Treatment of Osteosarcoma

Clinical Cancer Research, 2022
Abstract Purpose: Osteosarcoma, the most common bone malignancy in children, has a poor prognosis, especially when the tumor metastasizes to the lungs. Therefore, novel therapeutic strategies targeting both proliferation and metastasis of osteosarcoma are required.
Ai Takemoto, Satoshi Takagi, Takao Ukaji, Nobuhiko Gyobu, Mamoru Kakino, Miho Takami, Asami Kobayashi, Marie Lebel, Tokuichi Kawaguchi, Minoru Sugawara, Kazue Tsuji-Takayama, Kenji Ichihara, Yuki Funauchi, Keisuke Ae, Seiichi Matsumoto, Yoshiya Sugiura, Kengo Takeuchi, Tetsuo Noda, Ryohei Katayama, Naoya Fujita   +19 more
openaire   +2 more sources

Roles of Podoplanin in Malignant Progression of Tumor [PDF]

Cells, 2022
Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor development and normal development of the lung, kidney, and lymphatic vascular systems. PDPN is overexpressed in several tumors and is involved in their malignancy.
Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato   +2 more
openaire   +3 more sources

Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells

Molecular Cancer, 2010
Background Podoplanin, a mucin-like transmembrane glycoprotein, is reportedly expressed in a variety of malignant cells and is generally regarded as a factor for promoting tumor progression in conventional studies.
Suzuki Hanako, Onimaru Mitsuho, Yonemitsu Yoshikazu, Maehara Yoshihiko, Nakamura Seiji, Sueishi Katsuo   +5 more
doaj   +1 more source

Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study

Journal of Family Medicine and Primary Care, 2020
Aim: The present study was conducted to determine the podoplanin expression in odontogenic tumors and cysts. Materials and Methods: It consisted of 12 cases of the keratocystic odontogenic tumor (KCOT), 10 cases of ameloblastoma, 8 cases of dentigerous ...
Rohit Singh, Malwika Sisodia, Ranjan Sengupta, Annu Prakash Bhindwar, Karuna Bharti, Md Abu Nafe   +5 more
doaj   +1 more source

A comparative immunohistochemical study of expression of Syndecan-1 (CD138) and podoplanin in keratocystic odontogenic tumor, orthokeratinized odontogenic cyst and dentigerous cyst

Indian Journal of Dental Sciences, 2021
Background: Odontogenic lesions can bring about diagnostic challenges due to overlapping histology among pathologists. Thus, there are few tumor markers that provide accurate diagnosis.
Alka Chahar, Pooja Narain, Naveen Chahar, Jagriti Gupta, Arpita Kabiraj   +4 more
doaj   +1 more source

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin

Platelets, 2018
Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a
Stacey A. Langan, Leyre Navarro-Núñez, Steve P. Watson, Gerard B. Nash   +3 more
doaj   +1 more source