Results 41 to 50 of about 11,879 (214)

CLEC-2/podoplanin and thromboinflammation [PDF]

Blood, 2017
In this issue of Blood, Payne et al revealed a novel function of the platelet C–type lectin-like receptor 2 (CLEC-2)/podoplanin interaction in thromboinflammation: podoplanin expression is upregulated in the vessel wall during venous thrombosis. Venous thrombosis is prevented in the absence of CLEC-2.1 The role of platelet CLEC-2 in thromboinflammation
openaire   +2 more sources

Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin

, 2010
The membrane glycoprotein podoplanin is expressed by several types of human cancers and might be associated with their malignant progression. Its exact biological function and molecular targets are unclear, however.
Moch, H, Gruber, S, Hegyi, Ivan, Albinger-Hegyi, Andrea, Detmar, Michael, Andrea Albinger-Hegyi, Ivan Hegyi, Leah N. Cueni, Silke Gruber, Albinger-Hegyi, A, Detmar, M, Rainer Kunstfeld, Cueni, Leah N, Kunstfeld, Rainer, Jay W. Shin, Cueni, L N, Shin, Jay W, Moch, Holger, Kunstfeld, R, Shin, J W, Gruber, Silke, Michael Detmar, Hegyi, I, Holger Moch   +23 more
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Podoplanin-positive cells are a hallmark of encapsulating peritoneal sclerosis [PDF]

, 2010
BACKGROUND: Encapsulating peritoneal sclerosis (EPS) and simple peritoneal sclerosis are important complications of long-term peritoneal dialysis (PD). Podoplanin is expressed by mesothelial cells and lymphatic vessels, which are involved in inflammatory
Wüthrich, Rudolf P; https://orcid.org/, Ziegler, Urs; https://orcid.org/, F. Reimold, Biegger, Dagmar, I. Edenhofer, N. Braun, P. Fritz, Gaspert, Ariana, D. M. Alscher, B. Bode-Lesniewska, Segerer, Stephan; https://orcid.org/, M. Kimmel, Reimold, Fabian, D. Biegger, R. P. Wuthrich, U. Ziegler, S. Segerer, Braun, Niko, Alscher, Dominik M, Kimmel, Martin, Fritz, Peter; https://orcid.org/, Bode-Lesniewska, Beata; https://orcid.org/, Edenhofer, Ilka, A. Gaspert   +23 more
core   +1 more source

Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas

Clinics, 2010
OBJECTIVE: To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer.
Filomena M Carvalho, Fabricia L Zaganelli, Bernardo G L Almeida, Joao Carlos Sampaio Goes, Edmund C Baracat, Jesus P Carvalho   +5 more
doaj   +1 more source

Podoplanin-Positive Fibroblasts Enhance Lung Adenocarcinoma Tumor Formation: Podoplanin in Fibroblast Functions for Tumor Progression

, 2011
During the metastatic process, cancer cells interact with vascular adventitial fibroblasts (VAF), which are the main components of the outermost connective tissue layer of blood vessels.
Takashi Ito, Yoichi Ohtaki, Kanji Nagai, Ayuko Hoshino, Genichiro Ishii, Hiroki Sasaki, Atsushi Ochiai, Kazuhiko Aoyagi   +7 more
core   +1 more source

Distribution of podoplanin-expressing cells in the mouse nervous systems. [PDF]

, 2014
福岡歯科大学博士（歯学）2013年度Podoplanin is a mucin-type glycoprotein which was first identified in podocytes. Recently, podoplanin has been successively reported as a marker for brain and peripheral nerve tumors, however, the distribution of podoplanin-expressing ...
Tomooka, Miwa, Kaji, Chiaki, Sawa, Yoshihiko, Kojima, Hiroshi   +3 more
core   +1 more source

Phenotypically heterogeneous podoplanin-expressing cell populations are associated with the lymphatic vessel growth and fibrogenic responses in the acutely and chronically infarcted myocardium.

PLoS ONE, 2017
Cardiac lymphatic vasculature undergoes substantial expansion in response to myocardial infarction (MI). However, there is limited information on the cellular mechanisms mediating post-MI lymphangiogenesis and accompanying fibrosis in the infarcted adult
Maria Cimini, Antonio Cannatá, Gianandrea Pasquinelli, Marcello Rota, Polina Goichberg   +4 more
doaj   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Example of the podoplanin “low” pattern.

, 2012
A peritoneal biopsy from an EPS patient was stained with monoclonal antibodies against podoplanin (A, C), and consecutive sections were stained with a monoclonal antibody against SMA (B, D, orig. X200).
Seth L. Alper (107061), Peter Fritz (59203), Fabian Reimold (107060), Clemens D. Cohen (107065), M. Dominik Alscher (107057), Niko Braun (107056), Stephan Segerer (88027), Dagmar Biegger (107063), Maja Lindenmeyer (107064), Rudolf P. Wüthrich (103623), Joerg Latus (107058), Martin Kimmel (107062), Ilka Edenhofer (107059)   +12 more
core   +1 more source