Results 41 to 50 of about 11,070 (170)

Example of the podoplanin “low” pattern.

, 2012
A peritoneal biopsy from an EPS patient was stained with monoclonal antibodies against podoplanin (A, C), and consecutive sections were stained with a monoclonal antibody against SMA (B, D, orig. X200).
Seth L. Alper (107061), Peter Fritz (59203), Fabian Reimold (107060), Clemens D. Cohen (107065), M. Dominik Alscher (107057), Niko Braun (107056), Stephan Segerer (88027), Dagmar Biegger (107063), Maja Lindenmeyer (107064), Rudolf P. Wüthrich (103623), Joerg Latus (107058), Martin Kimmel (107062), Ilka Edenhofer (107059)   +12 more
core   +1 more source

Podoplanin is a useful prognostic marker and indicates better differentiation in lung squamous cell cancer patients? A systematic review and meta-analysis

BMC Cancer, 2020
Background The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis among squamous cancers.
Liya Hu, Peng Zhang, Qi Mei, Wei Sun, Lei Zhou, Tiejun Yin   +5 more
doaj   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Corneal transplantation: Restoring sight to the blind

Acta Ophthalmologica, EarlyView.
Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley   +1 more source

Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma

Molecular Therapy: Oncolytics, 2022
Glioblastoma is a devastating malignant brain tumor with a poor prognosis despite standard therapy. Podoplanin (PDPN), a type I transmembrane mucin-like glycoprotein that is overexpressed in various cancers, is a potential therapeutic target for the ...
Lushun Chalise, Akira Kato, Masasuke Ohno, Sachi Maeda, Akane Yamamichi, Shunichiro Kuramitsu, Satoshi Shiina, Hiromi Takahashi, Sachiko Ozone, Junya Yamaguchi, Yukinari Kato, Yumi Rockenbach, Atsushi Natsume, Tomoki Todo   +13 more
doaj   +1 more source

Super‐Enhancer Formation in Scirrhous Gastric CAFs, and the Presence of a Stromal Field in Non‐Cancerous Tissues

Cancer Science, EarlyView.
While CAFs are produced as a result of education by cancer cells in non‐scirrhous gastric cancer, normal fibroblasts of scirrhous gastric cancer patients are already pre‐conditioned, forming a stromal field for scirrhous gastric cancer. ABSTRACT Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer ...
Yoshimi Yasukawa, Naoko Hattori, Yu‐Yu Liu, Masayuki Tobo, Genki Yamagishi, Takahiro Irie, Shigeki Sekine, Tohru Kiyono, Satoshi Yamashita, Yukinori Yamagata, Takaki Yoshikawa, Yasuyuki Seto, Toshikazu Ushijima   +12 more
wiley   +1 more source

Evaluation of Podoplanin in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Scientifica, 2015
Background. Recent studies have demonstrated that podoplanin was expressed in some dysplastic lesions adjacent to primary oral cancers suggesting that podoplanin expression may occur in early oral tumorigenesis and lymphangiogenesis and therefore is ...
Ashok Patil, Kishor Patil, Suyog Tupsakhare, Mahesh Gabhane, Shrikant Sonune, Shilpa Kandalgaonkar   +5 more
doaj   +1 more source

Epithelial‐Mesenchymal Transition, Immune Response, and Extracellular Matrix Remodelling in Oral Cancer

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Aim This retrospective study investigates the interplay between epithelial‐mesenchymal transition (EMT) and immune response within the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC). Methodology Immunohistochemistry was conducted on OSCC specimens to evaluate the expression of podoplanin (PDP), E‐cadherin (CDH1), vimentin (
Nicole Lonni, Camilla Kammer Pereira, Amanda Maciel Costa, Aline Hsiao Bona, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Elena Riet Correa Rivero   +7 more
wiley   +1 more source

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

Platelets, 2018
The podoplanin-CLEC-2 axis is critical in mice for prevention of hemorrhage in the cerebral vasculature during mid-gestation. This raises the question as to how platelets are captured by podoplanin on neuroepithelial cells in a high shear environment. In
Stephanie E. Lombard, Alice Y. Pollitt, Craig E. Hughes, Ying Di, Tom Mckinnon, Chris A. O’callaghan, Steve P. Watson   +6 more
doaj   +1 more source

Topological analysis of the human lymph node reticular network predicts outcome in breast cancer

The Journal of Pathology, Volume 269, Issue 3, Page 348-362, July 2026.
Abstract Axillary LNs (ALNs) initiate immune responses in breast cancer (BC) but how and when ALNs become dysfunctional, facilitating metastasis, is unclear. The fibroblastic reticular cell (FRC) network within ALNs provides structural support and mediates immune homeostasis, but we have yet to elucidate whether this network changes during BC ...
Amy M Llewellyn, Sharon L D'Costa, Cheun YR Lam, Jasmine A Gore, Veronika Lachina, Daniel J Shewring, Sophie E Acton, Kalnisha Naidoo   +7 more
wiley   +1 more source