Results 61 to 70 of about 11,070 (170)

Expression of podoplanin in oral premalignant and malignant lesions and its potential as a biomarker

open access: yesIndian Journal of Dental Research, 2014
Aim: To analyze and compare the expression of podoplanin in normal oral tissues, leukoplakia and oral squamous cell carcinoma (OSCC) and to predict its use as a biomarker. Materials and Methods: Ninety-two formalin fixed paraffin embedded tissue samples
J Logeswari   +4 more
doaj   +1 more source

Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis

open access: yesCells, 2020
Podoplanin is a small transmembrane mucin-like glycoprotein that plays a crucial role in the development of the lung, heart and lymphatic vascular system.
Marko Sesartić   +3 more
doaj   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang   +3 more
wiley   +1 more source

Podoplanin Associates with CD44 to Promote Directional Cell Migration

open access: yes, 2010
Podoplanin is a transmembrane glycoprotein up-regulated in different human tumors, especially those derived from squamous stratified epithelia (SCCs).
Parsons, Maddy; id_orcid   +15 more
core   +1 more source

The structure of CLEC-2: mechanisms of dimerization and higher-order clustering

open access: yesPlatelets, 2021
The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent.
Eleyna M Martin   +5 more
doaj   +1 more source

Multi‐omics analysis identifies a major histocompatibility complex class II‐associated antigen‐presenting cancer‐associated fibroblast‐like state linked to the nuclear factor erythroid 2‐related factor 2‐karyopherin subunit beta 1 axis in nonsmall cell lung cancer

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
NSCLC contains an MHC‐II‐associated antigen‐presenting CAF‐like (apCAF‐like) state regulated by the NRF2‐KPNB1 axis. NRF2/KPNB1 signaling suppresses CIITA‐dependent antigen presentation and T‐cell activation, whereas inhibition of this pathway enhances antitumor immunity and improves responsiveness to anti‐PD‐1 therapy.
Fei Zheng   +5 more
wiley   +1 more source

Case Report: Synchronous Manifestations of Kaposi Sarcoma Herpesvirus‐Associated Disorders

open access: yesCancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Kaposi sarcoma herpes virus (KSHV) is associated with multiple clinical manifestations, including primary effusion lymphoma, an aggressive CD38+ B cell lymphoma with a plasmablastic phenotype. Case This case describes an antiretroviral therapy‐adherent person with HIV who presented with concurrent KSHV‐related disorders of Kaposi ...
Kandice Roberts   +13 more
wiley   +1 more source

Distribution of podoplanin-expressing cells in the mouse nervous systems.

open access: yes, 2014
福岡歯科大学博士(歯学)2013年度Podoplanin is a mucin-type glycoprotein which was first identified in podocytes. Recently, podoplanin has been successively reported as a marker for brain and peripheral nerve tumors, however, the distribution of podoplanin-expressing ...
Tomooka, Miwa   +3 more
core   +1 more source

Immunohistochemical evaluation of podoplanin in odontogenic tumours & cysts using anti-human podoplanin antibody

open access: yesJournal of Oral Biology and Craniofacial Research, 2017
Background: Odontogenic Cysts & tumors originate through some aberration from the normal pattern of odontogenesis. Ameloblastoma is one of the most frequent intraosseous odontogenic tumors.
Namrata Singhal   +5 more
doaj   +1 more source

Development and functional adaptation of intestinal macrophages across the lifespan

open access: yesClinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa   +2 more
wiley   +1 more source

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