Results 111 to 120 of about 130,774 (227)

Descrição atualizada da paralisia cerebral

Developmental Medicine &Child Neurology, EarlyView.
Resumo A paralisia cerebral (PC) é um termo descritivo amplamente utilizado para um espectro de deficiências motoras causadas por lesão ou malformação cerebral não progressiva ocorrida durante as fases iniciais do desenvolvimento. Avanços recentes nas áreas da genética, de pesquisa em inflamação e em neurofisiologia têm refinado a compreensão ...
Bernard Dan, Peter Rosenbaum, Lucinda Carr, Martin Gough, John Coughlan, Nonyelum Nweke   +5 more
wiley   +1 more source

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

The Augmented Hat‐Matrix of Hierarchical Generalised Linear Models and Its Use in Leverage Diagnostics

International Statistical Review, EarlyView.
Summary Defining a ‘hat‐matrix’ for a model is essential in many model diagnostic procedures, as it acts as an orthogonal projector from the observation space to the model space. In this paper, we introduce a unique Hat‐matrix for the class of hierarchical generalised linear models (HGLMs), which includes, as a special case, the subclass of generalised
Gianfranco Lovison, Mariangela Sciandra, Alessandro Albano, Chiara Di Maria   +3 more
wiley   +1 more source

The Random Power Function for Tests Based on Pivotal Quantities

International Statistical Review, EarlyView.
Summary In clinical trials planning, evaluation of the probability of success of an experiment is of central interest, for instance, in sample size determination. This assessment typically involves analyses of the power function of a test on a parameter of interest, such as a relevant treatment effect.
Fulvio De Santis, Stefania Gubbiotti, Francesco Mariani   +2 more
wiley   +1 more source

When indemnity insurance fails: Parametric coverage under binding budget and risk constraints

Journal of Risk and Insurance, EarlyView.
Abstract In high‐risk environments, traditional indemnity insurance is often unaffordable or ineffective, despite its well‐known optimality under expected utility. We compare excess‐of‐loss indemnity insurance with parametric insurance within a common mean‐variance framework, allowing for fixed costs, heterogeneous premium loadings, and binding budget ...
Benjamin Avanzi, Debbie Kusch Falden, Mogens Steffensen   +2 more
wiley   +1 more source

Premature ovarian insufficiency: When ovaries retire early

Annals, Academy of Medicine, Singapore
Introduction: Premature ovarian insufficiency (POI) refers to loss of ovarian activity before the age 40 years. POI has significant detrimental effects on health (infertility, cardiovascular diseases, type 2 diabetes, reduced bone density, dementia ...
Stella Rizalina Sasha Sugianto, Lisa Webber, Farah Husain Safdar, Veronique Viardot-Foucault, Sadhana Nadarajah, Jiin Ying Lim, Ee Shien Tan, Tze Tein Yong, Rukshini Puvanendran   +8 more
doaj   +1 more source

Religious Participation After Covid‐19: Evidence From US Catholic Dioceses and Smartphone Data

Journal for the Scientific Study of Religion, EarlyView.
ABSTRACT How do religious rules and regulations affect behavior? We examine this question using changes in Catholic regulations during the Covid‐19 pandemic combined with mobility data from 15 million smartphone users from 2019 to 2022. We first document overall trends: Total religious attendance declined sharply in March 2020 and thereafter recovered ...
Angela Cools, Carlos Esparza S.J., Jiwon Park   +2 more
wiley   +1 more source

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

Obesity Reviews, EarlyView.
ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management.
Chrysa Episkopou, Dimitrios Aletras, Afroditi Kita, Aleksandra Luszczynska, Maria Kafyra, Eva Karaglani, Yannis Manios, Maira Bes‐Rastrollo, Anna Ek, Ioannis Ioakeimidis, Ioanna Panagiota Kalafati, Ana Rito, Alexis Kyriacou, Anestis Dougkas, Julie Anne Nazare, Louise Seconda, Gillian Santorelli, Vassilios Fanos, Karri Silventoinen, Terho Lehtimäki, George V. Dedoussis, Anastasios Delopoulos, on behalf of the BETTER4U consortium, Project Coordinator George Dedoussis   +23 more
wiley   +1 more source

Natural and CRISPR/Cas9 Editing Variations of Dual‐uORFs Synergistically Increase the Nutritional Value of Silage Maize Feed

Plant Biotechnology Journal, EarlyView.
ABSTRACT The precise enhancement of nutritional quality in silage maize is a core strategy for increasing livestock production efficiency. Through evolutionary analysis of multiple plant species, we identified two functionally synergistic upstream open reading frames (uORF1 and uORF2) within the 5′ untranslated region of the gene encoding GDP‐L ...
Jing Zhou, Xi Wang, Yajing Zhang, Xinhao Luo, Shuyao Quan, Jie Ji, Lixue Sun, Xinyang Chen, Jin Chen, Jianbo Cheng, Jun Fan, Changsheng Li, Beijiu Cheng, Xiaoyu Li   +13 more
wiley   +1 more source

POI

, 2014
POI
core   +2 more sources