Results 111 to 120 of about 3,175,966 (336)

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Accuracy of point-of-care SARS-CoV-2 detection using buccal swabs in pediatric emergency departments

Microbiology Spectrum
To optimize the identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected children, specimen collection and testing method are crucial considerations.
Stephen B. Freedman, Kelly Kim, Gabrielle Freire, Alicia Kanngiesser, April Kam, Quynh Doan, Bruce Wright, Maala Bhatt, Simon Berthelot, Jocelyn Gravel, Brett Burstein, Jason Emsley, Ahmed Mater, Robert Porter, Naveen Poonai, Deepti Reddy, Richard J. Webster, David M. Goldfarb, Kirk Leifso, Roger Zemek   +19 more
doaj   +1 more source

Cost-effectiveness of Antiviral Stockpiling and Near-Patient Testing for Potential Influenza Pandemic

Emerging Infectious Diseases, 2008
A decision analytical model was developed to investigate the cost-effectiveness of stockpiling antiviral (AV) drugs for a potential influenza pandemic in the United Kingdom and the possible role of near-patient testing in conserving AV drug stocks. Under
M. Ruby Siddiqui, W. John Edmunds
doaj   +1 more source

Exploring Disk Galaxy Dynamics Using IFU Data [PDF]

, 2008
In order to test the basic equations believed to dictate the dynamics of disk galaxies, we present and analyze deep two-dimensional spectral data obtained using the PPAK integral field unit for the early-type spiral systems NGC 2273, NGC 2985, NGC 3898 ...
A. Aragn-Salamanca, Bedregal, Bedregal, Binney, Bottema, Bottema, Cappellari, E. Noordermeer, Emsellem, Gerssen, Jeans, Kelz, Kuijken, Lewis, M. R. Merrifield, Merrett, Merrifield, Noordermeer, Noordermeer, Noordermeer, Noordermeer, Roth, Shapiro, Snchez, van der Kruit, van Dokkum, Verheijen   +26 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Tackling SNR at low-field: a review of hardware approaches for point-of-care systems. [PDF]

MAGMA, 2023
Webb A, O'Reilly T.
europepmc   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Clinical measurements obtained from point-of-care ultrasound images to assess acquisition skills

The Ultrasound Journal, 2019
Background Current methods of assessing competence in acquiring point-of-care ultrasound images are inadequate. They rely upon cumbersome rating systems that do not depend on the actual outcome measured and lack evidence of validity.
Brian P. Lucas, Antonietta D’Addio, Clay Block, Harold L. Manning, Brian Remillard, James C. Leiter   +5 more
doaj   +1 more source