Results 121 to 130 of about 3,351,259 (336)

First Clinical Description of Coagulation of Whole Blood with Resonant Acoustic Rheometry

Diagnostics
Background/Objectives: The timely evaluation of blood clot formation and breakdown is essential in the care of patients with severe bleeding or critical illness.
Connor M. Bunch, Weiping Li, Kiera Downey, Timothy L. Hall, Allen Chehimi, Samuel J. Thomas, Afsheen Mansoori, Miguel Velasco, Marie N. Karam, Jenny Chen, Jacob Tuttle, Matthew R. Walsh, Scott G. Thomas, Mark M. Walsh, Joseph B. Miller, Jan P. Stegemann, Cheri X. Deng   +16 more
doaj   +1 more source

A System for Accessible Artificial Intelligence

, 2017
While artificial intelligence (AI) has become widespread, many commercial AI systems are not yet accessible to individual researchers nor the general public due to the deep knowledge of the systems required to use them.
D. A. Ferrucci, EM Ronald, F Pedregosa, Ignacio Arnaldo, Jason H. Moore, JH Moore, JH Moore, JH Moore, Karthik Kannappan, Randal S. Olson, RS Olson, Sara Silva, William La Cava, William La Cava   +13 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Clinical measurements obtained from point-of-care ultrasound images to assess acquisition skills

The Ultrasound Journal, 2019
Background Current methods of assessing competence in acquiring point-of-care ultrasound images are inadequate. They rely upon cumbersome rating systems that do not depend on the actual outcome measured and lack evidence of validity.
Brian P. Lucas, Antonietta D’Addio, Clay Block, Harold L. Manning, Brian Remillard, James C. Leiter   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Handheld Point-of-Care System for Rapid Detection of SARS-CoV-2 Extracted RNA in under 20 min

, 2021
Jesús Rodríguez-Manzano, Kenny Malpartida-Cardenas, Nicolas Moser, Ivana Pennisi, Matthew L. Cavuto, Luca Miglietta, Ahmad Moniri, Rebecca Penn, Giovanni Satta, Paul Randell, Frances Davies, Frances Bolt, William Barclay, Alison Holmes, Pantelis Georgiou   +14 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Intrauterine Pregnancy Detection and Gestational Age Assessment During Early Pregnancy by a Handheld Point-Of-Care Ultrasound Device Compared to a High-End Ultrasound System. An Accuracy and Reliability Study

, 2022
Mariela Skendi, Roxane Liard, Charlotte Besacier, Jean-Michel Corréas, Sohela Moussaoui, Julie Chastang, Gladys Ibanez   +6 more
openalex   +2 more sources

Deeply-Dyed Nanobead System Based Lateral Flow Assay for Rapid Point-of-Care Drug Testing [PDF]

, 2021
Lingzhi Fan, Jianbing Wu, Jing Yang, Fugang Li, Wannian Yan, Fei Tan, Madeline Zhang, Mohamed S. Draz, Han Huanxing, Pengfei Zhang   +9 more
openalex   +1 more source