Results 191 to 200 of about 10,528,066 (300)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [¹¹C]PiB amyloid imaging. [PDF]

EJNMMI Phys, 2021
Laymon CM, Minhas DS, Royse SK, Aizenstein HJ, Cohen AD, Tudorascu DL, Klunk WE.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Enhanced supercritical angle localization microscopy through point spread function modeling. [PDF]

Biomed Opt Express
Khan SA, Lidke KA, Liu S.
europepmc   +1 more source

Effect of Point Spread Function Deconvolution in Reconstruction of Brain ¹⁸F-FDG PET Images on the Diagnostic Thinking Efficacy in Alzheimer's Disease. [PDF]

Front Med (Lausanne), 2021
Doyen M, Mairal E, Bordonne M, Zaragori T, Roch V, Imbert L, Verger A.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function. [PDF]

Nat Commun
You X, Fan Z, Zhang H, Xie Z, Li C, Gui H, Zou G, Zhan Q, Liu J, Liu X, Zhang D.   +10 more
europepmc   +1 more source

Joint Estimation of Trajectory and Model Parameters for Single Particle Tracking of 3D Confined Diffusion Using the Double-Helix Point Spread Function. [PDF]

IFAC Pap OnLine, 2021
Lin Y, Sharifi F, Andersson SB.
europepmc   +1 more source

Generalizing Ripley's K function to inhomogeneous populations [PDF]

In spatial statistics, Ripley's K function (Ripley, 1977) is a classical tool to analyse spatial point patterns. Yet, it faces two major limits: it is only pertinent for homogeneous point processes and it does not allow the weighting of points.We ...
Florence Puech, Eric Marcon
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source