Results 101 to 110 of about 146,403 (298)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Physical and Mathematical Modeling of a Wave Energy Converter Equipped with a Negative Spring Mechanism for Phase Control

Energies, 2018
A wave-energy converter has been studied through the combination of laboratory experiments and numerical simulations. The converter model is a semi-submerged axi-symmetric buoy with a circular cross section with a diameter of 26 cm at the water plane ...
Amélie Têtu, Francesco Ferri, Morten Bech Kramer, Jørgen Hals Todalshaug   +3 more
doaj   +1 more source

A New Solution for Sea Wave Energy Harvesting, the Proposal of an Ironless Linear Generator

Journal of Marine Science and Engineering, 2020
The paper investigates an innovative ironless linear generator, installable inside a wave energy converter, in order to produce electricity from sea waves.
Domenico Curto, Alessia Viola, Vincenzo Franzitta, Marco Trapanese, Fabio Cardona   +4 more
doaj   +1 more source

Large-Scale Structure at z~2.5

, 1995
We have made a statistically complete, unbiased survey of C IV systems toward a region of high QSO density near the South Galactic Pole using 25 lines of sight spanning $1 ...
A.J.S. Hamilton, A.P.S. Crotts, C.B. Foltz, C.B. Foltz, C.C. Steidel, C.W. Misner, J. Heisler, M. Davis, M. Rauch, M.U. SubbaRao, N. Kaiser, P. Coles, P. Jakobsen, P.J. Young, R. Weygaert van de, T.J. Broadhurst, W.L.W. Sargent   +16 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Analysis on Energy Harvesting Mechanism of Compartmented Buoy Wave Energy Converter

南方能源建设
[Objective] The motion attitude of oscillating buoy wave energy converters significantly impacts energy capture, and the compartmentalization characteristics of the buoy are closely related to its motion attitude. Therefore, it has significant importance
Yang LIU, Yuhang LI, Xin GAO, Tongshun YU, Yongwei REN   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Performance Analysis of a Floating Wind–Wave Power Generation Platform Based on the Frequency Domain Model

Journal of Marine Science and Engineering
Integrating wave energy converters (WECs) onto floating offshore wind turbine platforms has emerged as a recent focal point of research aiming to achieve synergistic marine energy utilization and enhance the spatial efficiency of renewable energy.
Mingsheng Chen, Jiang Deng, Yi Yang, Hao Zhou, Tao Tao, Shi Liu, Liang Sun, Lin Hua   +7 more
doaj   +1 more source