Results 101 to 110 of about 147,233 (294)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Stochastic Rating of Storage Systems in Isolated Networks with Increasing Wave Energy Penetration

Energies, 2013
The future success of wave energy in the renewable energy mix depends on the technical advancements of the specific components and systems, on the grid access availability and, ultimately, on the economical profitability of the investment.
Elisabetta Tedeschi, Maider Santos, Marta Molinas, Jonas Sjolte   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Performance Analysis of a Floating Wind–Wave Power Generation Platform Based on the Frequency Domain Model

Journal of Marine Science and Engineering
Integrating wave energy converters (WECs) onto floating offshore wind turbine platforms has emerged as a recent focal point of research aiming to achieve synergistic marine energy utilization and enhance the spatial efficiency of renewable energy.
Mingsheng Chen, Jiang Deng, Yi Yang, Hao Zhou, Tao Tao, Shi Liu, Liang Sun, Lin Hua   +7 more
doaj   +1 more source

Physical and Mathematical Modeling of a Wave Energy Converter Equipped with a Negative Spring Mechanism for Phase Control

Energies, 2018
A wave-energy converter has been studied through the combination of laboratory experiments and numerical simulations. The converter model is a semi-submerged axi-symmetric buoy with a circular cross section with a diameter of 26 cm at the water plane ...
Amélie Têtu, Francesco Ferri, Morten Bech Kramer, Jørgen Hals Todalshaug   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Atmosphere and Spectral Models of the Kepler-Field Planets HAT-P-7b and TrES-2

, 2010
We develop atmosphere models of two of the three Kepler-field planets that were known prior to the start of the Kepler mission (HAT-P-7b and TrES-2). We find that published Kepler and Spitzer data for HAT-P-7b appear to require an extremely hot upper ...
Burrows, Adam, Spiegel, David S.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Energy absorption from parks of point‐absorbing wave energy converters in the Swedish exclusive economic zone

Energy Science & Engineering, 2020
In a future energy system based on renewable energy sources, wave energy will most likely play a role due to its high energy potential and low intermittency.
Jens Engström, Malin Göteman, Mikael Eriksson, Mikael Bergkvist, Erik Nilsson, Anna Rutgersson, Erland Strömstedt   +6 more
doaj   +1 more source