Results 121 to 130 of about 5,624,947 (339)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Energy absorption from parks of point‐absorbing wave energy converters in the Swedish exclusive economic zone

Energy Science & Engineering, 2020
In a future energy system based on renewable energy sources, wave energy will most likely play a role due to its high energy potential and low intermittency.
Jens Engström, Malin Göteman, Mikael Eriksson, Mikael Bergkvist, Erik Nilsson, Anna Rutgersson, Erland Strömstedt   +6 more
doaj   +1 more source

Theoretical Spectra and Light Curves of Close-in Extrasolar Giant Planets and Comparison with Data

, 2008
We present theoretical atmosphere, spectral, and light-curve models for extrasolar giant planets (EGPs) undergoing strong irradiation for which {\it Spitzer} planet/star contrast ratios or light curves have been published (circa June 2007). These include
A. Burrows, I. Hubeny, J. Budaj, Johns-Krull C. M.   +3 more
core   +1 more source

Hydrodynamic Performance of Heaving Motion on Cylinder and Conical Two-Body Point Absorber in Low Wave Energy

, 2022
Mohd Amin Hakim Ramli, Muhammad Adli Mustapa, Rohaizad Hafidz Rozali, E A Azrulhisham   +3 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A wave-to-wire analysis of the adjustable draft point absorber wave energy converter coupled with a linear permanent-magnet generator

, 2023
Jian Tan, Henk Polinder, Antonio Jarquin Laguna, Sape A. Miedema   +3 more
openalex   +1 more source

Error Sensing Strategy for Active Control of Low‐Frequency Sound Absorption of Micro‐Perforated Panel Absorber by Using a Point Force Controlled Thin Plate [PDF]

, 2021
Xiyue Ma, Kean Chen, Lei Wang, Yang Liu
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Laboratory Testing to Assess the Feasibility of Polyurethane Flat Belts for Marine Energy Applications

Journal of Marine Science and Engineering
Polyurethane flat belts have received limited scientific attention as load-bearing elements in marine energy systems, particularly in applications involving dynamic tensile and bending loads.
Justin Panzarella, Scott Jenne, Andrew Simms   +2 more
doaj   +1 more source