Results 61 to 70 of about 1,830,967 (336)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

EQUILATERAL POINT SETS IN ELLIPTIC GEOMETRY

Indagationes Mathematicae (Proceedings), 1966
This chapter highlights equilateral point sets in elliptic geometry. Elliptic space of r−1 dimensions E r−1 is obtained from r -dimensional vector space R r with inner product ( a , b ). For 1 , any k -dimensional linear subspace R k of R r is called a ( k−1 )-dimensional elliptic subspace E k−1 .
van Lint, J.H., Seidel, J.J.
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

EXPERIMENTS WITH UAS IMAGERY FOR AUTOMATIC MODELING OF POWER LINE 3D GEOMETRY [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
The ideal mapping technology for transmission line inspection is the airborne LiDAR executed from helicopter platforms. It allows for full 3D geometry extraction in highly automated manner.
G. Jóźków, B. Vander Jagt, C. Toth
doaj   +1 more source

Absolute Embeddings of Point–Line Geometries

Journal of Algebra, 2001
The paper concerns the existence of absolute embeddings \(e\) of point-line geometries \(\Gamma=({\mathcal P},{\mathcal L})\), that is, any embedding of \(\Gamma\) in some projective space can be derived from \(e\) by projecting onto suitable quotient spaces.
Kasikova, A, Shult, E
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Automatic normal orientation in point clouds of building interiors

, 2019
Orienting surface normals correctly and consistently is a fundamental problem in geometry processing. Applications such as visualization, feature detection, and geometry reconstruction often rely on the availability of correctly oriented normals.
J Wang, K Takayama, N Schertler, P Mullen, R Schnabel, SG Parker   +5 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Autoencoder Architectures for Low-Rate Sparse Point Cloud Geometry Coding

IEEE Access
Efficient compression of sparse point cloud geometry remains a critical challenge in 3D content processing, particularly for low-rate scenarios where conventional codecs struggle to maintain efficiency. This work proposes a system-level framework for low-
Ivaylo Bozhilov, Radostina Petkova, Krasimir Tonchev, Agata Manolova, Vladimir Poulkov, H. Vincent Poor   +5 more
doaj   +1 more source

ON PRECISION ACOUSTIC WAVE CALCULATION IN A FREQUENCY DOMAIN

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, 2022
The accuracy of the calculation of acoustic problems formulated in the frequency domain is presented in this work. The issues of the acoustic point sources modelling were discussed and the influence of frequency as well as the impact of the geometry of ...
Tomasz Rymarczyk, Jan Sikora
doaj   +1 more source