Results 111 to 120 of about 199,997 (276)

THE POINT LOAD TEST, GEOTECHNICAL DATABASE CREATED FROM INVESTIGATIONS FOR INFRASTRUCTURE PROJECTS IN THE REPUBLIC OF MACEDONIA – ANISOTROPY ANALYSIS

open access: yes, 2018
The point load test is one of the most exploited techniques to obtain preliminary information of the strength of the rocks. The paper deals with statistical analysis of large amount of results from the test, obtained for the needs of geotechnical ...
Misajleski, Zoran   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Modelling of a stand alone photovoltaic system with dedicated hybrid battery energy storage system

open access: yes, 2012
Includes abstract.Includes bibliographical references.The purpose of this thesis project was to model and simulate a stand-alone photovoltaic (PV) plant that utilized the maximum power point tracking (MPPT) technique and included a hybrid battery energy ...
Vanden Eynde, Nicholas
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Development of LRFD Procedures for Bridge Pile Foundations in Iowa: Volume II: Field Testing of Steel Piles in Clay, Sand, and Mixed Soils and Data Analysis, September 2011

open access: yes, 2011
In response to the mandate on Load and Resistance Factor Design (LRFD) implementations by the Federal Highway Administration (FHWA) on all new bridge projects initiated after October 1, 2007, the Iowa Highway Research Board (IHRB) sponsored these ...

core  

Correlation between uniaxial compressive strength and point-load index strength [PDF]

open access: yes, 2009
In verifying the material properties of rock, laboratory test need to be carried out to ensure a safe design of structures. Among the most common rock properties verified in laboratory are uniaxial compressive strength test (UCS) and point-load index ...
Sundara, Parameswary
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Experimental Study of the Stability of Multilateral Well Junctions using Point Load Test [PDF]

open access: yes, 2011
The strength of rock formation around multilateral (ML) well junctions is important. The objectives of this project were to determine the strength of cylindrical shape rock samples drilled with different geometrical configuration (inclination angle of
Hassan, Afiq Aiman
core  

The Uniaxial Compressive Strength of Soft Rock

open access: yesCivil Engineering Dimension, 2007
Soft rock is a term that usually refers to a rock material with a uniaxial compressive strength (UCS) less than 20 MPa. This low strength range might be influenced by physical characteristics, such as size, saturation, weathering and mineral content.
D. S. Agustawijaya
doaj  

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