Results 91 to 100 of about 199,997 (276)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Point Load Test for Estimation of Concrete Compressive Strength
, 1989 The point-load index is presented as a convenient alternate method for determining relative strength of concrete or as a method of estimating concrete compressive strength.
Richardson, David Newton
core
Effect of Textile Layers and Hydroxypropyl Methylcellulose on Flexural Behavior of TRLC Thin Plates
BuildingsTo examine the flexural toughness characteristics of textile-reinforced lightweight aggregate concrete (TRLC), a four-point bending test was conducted to assess the impact of varying numbers of textile layers and the inclusion of hydroxypropyl ...
Jiyang Wang +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Correlation between uniaxial compressive strength and point load strength index of granite sample [PDF]
, 2019 Uniaxial compressive strength (UCS) of rocks is an important parameter in geotechnical structure designs. Being difficult to obtain proper sample and the UCS test itself is expensive, indirect methods of estimating UCS were developed such as point load ...
Jasman, Nursyiqah
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Adaptive Dynamic Programming-based Tracking Controls of Multi-Motor Driven Systems
Taiyuan Ligong Daxue xuebao[Purposes] The unknown multi-motor driven load systems are addressed in this paper with game theory and adaptive dynamic programming. [Methods] The neural network (NN) is used to approximate the unknown dynamics. On the basis of the approximated dynamics,
LYU Yongfeng, JIAN Long
doaj +1 more source
Estimating the Collapse Point of a Transmission Line in a Developing Power Systems
Arid Zone Journal of Engineering, Technology and Environment, 2023 The trouble with a developing national grid is compounded by the fact that the power system supplies power to a vast number of loads which is fed by a number of generating units sometimes far from the load centers.
J. N. Onah +3 more
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