Results 71 to 80 of about 72,833 (270)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A study on surrounding rock characteristics inducing severe large deformation in tunnels and methods for determining its strength

Scientific Reports
The Haba Snow Mountain Tunnel experienced severe deformation caused by foliated metamorphic basalt. This rock has high metamorphism, easy weathering, and low strength.
Zhongsheng Tan, Jinpeng Zhao, Zonglin Li, Baojin Zhang   +3 more
doaj   +1 more source

The investigation on flexural performance of prestressed concrete-encased high strength steel beams [PDF]

Archives of Civil Engineering
This paper reports an experimental on the flexural performance of prestressed concrete-encased high-strength steel beams (PCEHSSBs). To study the applicability of high-strength steel (HSS) in prestressed concrete-encased steel beams (PCESBs), one simply ...
Jun Wang, Yurong Jiao, Menglin Cui, Wendong Yang, Xueqi Fang, Jun Yan   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Correlation Between P-wave Velocity and Strength Index for Shale to Predict Uniaxial Compressive Strength Value

MATEC Web of Conferences, 2017
Seismic refraction survey is a non destructive method used in site investigation to identify the seismic velocity subsurface strata. Although it is widely known, the reliability of the result is still doubtable for some reason as well as due to an ...
Awang H., Ahmad Rashidi N. R., Yusof M., Mohammad K.   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Investigation into the effect of length to diameter ratio on the point load strength index of Gosford sandstone

, 2015
Since the introduction of the point load test, size effect has been observed in the point load strength index. While considerable research has been undertaken to investigate the size effect in the point load strength index, and the general cause of size ...
Hagan, P ; https://orcid.org/, Masoumi, H, Saydam, S ; https://orcid.org/, Forbes, M   +3 more
core  

Accuracy of Point Load Index and Brazilian Tensile Strength in Predicting the Uniaxial Compressive Strength of the Rocks: A Comparative Study

Materials
Uniaxial compressive strength (UCS) of rocks is one of the main parameters required in the design of geotechnical projects such as tunnels, dams, or rock slopes. According to the literature, there are a large number of predictive regression equations to evaluate the UCS from the point load index (PLI) and Brazilian tensile strength (BTS).
Amin Jamshidi, Luís Sousa
openaire   +2 more sources