Results 51 to 60 of about 72,006 (214)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Scientific ReportsThe Haba Snow Mountain Tunnel experienced severe deformation caused by foliated metamorphic basalt. This rock has high metamorphism, easy weathering, and low strength.
Zhongsheng Tan +3 more
doaj +1 more source
The investigation on flexural performance of prestressed concrete-encased high strength steel beams [PDF]
Archives of Civil EngineeringThis paper reports an experimental on the flexural performance of prestressed concrete-encased high-strength steel beams (PCEHSSBs). To study the applicability of high-strength steel (HSS) in prestressed concrete-encased steel beams (PCESBs), one simply ...
Jun Wang +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Applied SciencesUniaxial compressive strength (UCS) is a fundamental parameter for rock engineering design and stability assessment, but direct laboratory testing is costly, time-consuming, and often difficult for weak or fractured rocks.
Jie Peng, Hengyu Liu, Yun Lin, Yanyan He
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
MATEC Web of Conferences, 2017 Seismic refraction survey is a non destructive method used in site investigation to identify the seismic velocity subsurface strata. Although it is widely known, the reliability of the result is still doubtable for some reason as well as due to an ...
Awang H. +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source