Results 111 to 120 of about 5,843,460 (297)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Tools and strategies for scarless allele replacement in Drosophila using CRISPR/Cas9
Fly, 2017 Genome editing via the CRISPR/Cas9 RNA-guided nuclease system has opened up exciting possibilities for genetic analysis. However, technical challenges associated with homology-directed repair have proven to be roadblocks for producing changes in the ...
Abigail M. Lamb +2 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Point Mutations in the α -Synuclein Gene
, 2003 Idiopathic Parkinson's disease (PD) is an age-dependent, neurodegenerative disorder and is predominantly sporadic. Only 20-30% of patients have a positive family history for PD with a complex mode of inheritance. In a few extended families, the disease is inherited as an autosomal dominant trait.
A, Parsian, J S, Perlmutter
openaire +2 more sources
Central Point Notice of Adopted Amendment (2008-12-29) [PDF]
, 2008 162 pp. Adopted 2008-12-29. Department of Land Conservation and Development Notice of Adopted AmendmentThe attached proposed amendment is the Central Point Transportation System Plan (TSP) which will be an element of the updated Central Point ...
Central Point (Or.)
core
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Taqman-MGB nanoPCR for Highly Specific Detection of Single-Base Mutations
International Journal of Nanomedicine, 2021 Zhenrui Xue,1– 3,* Minli You,2,3,* Ping Peng,1– 3,* Haoyang Tong,2,3 Wanghong He,2– 4 Ang Li,4 Ping Mao,1– 3 Ting Xu,1 Feng Xu,2,3 Chunyan Yao1 1Department of Transfusion Medicine, Southwest Hospital, Third Military Medical ...
Xue Z +9 more
doaj
Strategic plan: a framework for projected activities 2001-2005 / Pavee Point
, 2001 Pavee Point ...
Pavee Point Travellers Centre
core