Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Development of herbicide resistant crops through induced mutations
Advancements in Life Sciences, 2015 Herbicide resistance is an innate characteristic of crop plants. It enables them to survive and propagate even in the presence of lethal doses of herbicides in the surroundings. Genetic tolerance in crops towards herbicides may have several benefits.
Muhammad Rizwan +3 more
doaj
The F204S mutation in adrenodoxin oxidoreductase drives salinomycin resistance in Eimeria tenella
Veterinary ResearchSalinomycin is a polyether ionophore widely used for the treatment of coccidiosis in poultry. However, the emergence of coccidia strains resistant to salinomycin presents challenges for control efforts, and the mechanisms underlying this resistance in ...
Pei Sun +13 more
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
A Desmoplakin Point Mutation with Enhanced Keratin Association Ameliorates Pemphigus Vulgaris Autoantibody-Mediated Loss of Cell Cohesion [PDF]
, 2014 Carina Dehner +3 more
openalex +1 more source
Supplementary Material from CRISPR/Cas9-Mediated Point Mutation in <i>Nkx3.1</i> Prolongs Protein Half-Life and Reverses Effects <i>Nkx3.1</i> Allelic Loss [PDF]
, 2023 Cai Bowen +5 more
openalex +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Using Genetic Algorithms to Develop Strategies for the Prisoners Dilemma [PDF]
The Prisoner’s Dilemma, a simple two-person game invented by Merrill Flood & Melvin Dresher in the 1950s, has been studied extensively in Game Theory, Economics, and Political Science because it can be seen as an idealized model for real-world phenomena ...
Haider, Adnan
core +1 more source
Repeat-Induced Point Mutation and Other Genome Defense Mechanisms in Fungi
Microbiology spectrum, 2017 Eugene Gladyshev
semanticscholar +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source