Results 171 to 180 of about 5,843,460 (297)

A Single Point Mutation in GraS Drives Co-Evolution of Vancomycin Resistance and Virulence in <i>Staphylococcus aureus</i>. [PDF]

Microorganisms
Hu Z, Rao Y, Liu L, Guo Z, Wang Y, Shang W, Peng H.   +6 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The D826V point mutation in <i>IREB2</i> induces lipogenesis in adipose tissues. [PDF]

Front Cell Dev Biol
Lv Y, Wu C, Xiao J, Yang W, Wang C, Wang J, Huang J, Guo Z, Liao S.   +8 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Immunological Phenotyping of Mice with a Point Mutation in Cdk4. [PDF]

Biomedicines, 2023
Yabas M, Hoyne GF.
europepmc   +1 more source

Central Point Notice of Adopted Amendment (2011-04-29)

, 2011
65 pp. Adopted 2011-04-29. Department of Land Conservation and Development Notice of Adopted AmendmentRevision to the Flood Damage Prevention ordinance to make the revised Federal Emergency Management Agency (FEMA) Flood Insurance Rate Map (FIRM) panels ...
Central Point (Or.)
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Development of Radioligand Therapy-Responsive Syngeneic Prostate Models through Murine Prostate-Specific Membrane Antigen Point Mutation. [PDF]

ACS Pharmacol Transl Sci
Richard M, Louis B, Taddio MF, Jeanjean P, Diaz Garcia-Prada C, Swaidan A, Carlucci G, Boudreault PL, Besserer-Offroy E, Mona CE.   +9 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Wheat cleistogamy is expressed by the dosage effect of homoeologous <i>AP2</i> mutant alleles carrying a point mutation in the miR172 target site. [PDF]

Breed Sci
Kakeda K, Nanape AB, Ogawa H, Nitta M.
europepmc   +1 more source