Results 201 to 210 of about 665,827 (257)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Flagellar point mutation causes social aggregation in laboratory-adapted <i>Bacillus subtilis</i> under conditions that promote swimming. [PDF]

J Bacteriol
Alvi S, Mondelo VD, Boyle J, Buck A, Gejo J, Mason M, Matta S, Sheridan A, Kreutzberger MAB, Egelman EH, McLoon A.   +10 more
europepmc   +1 more source

The point mutation A1387G in the 16S rRNA gene confers aminoglycoside resistance in <i>Campylobacter jejuni</i> and <i>Campylobacter coli</i>. [PDF]

Antimicrob Agents Chemother
Zarske M, Werckenthin C, Golz JC, Stingl K.   +3 more
europepmc   +1 more source

Synchronous Double Primary Lung Adenocarcinomas With EGFR L858R Point Mutation and MET Exon 14 Skipping Mutation. [PDF]

J Med Cases
Ando S, Futami S, Azuma K, Nishimatsu K, Shirasaka T, Minami S.   +5 more
europepmc   +1 more source

A new point mutation in the HC-Pro of potato virus Y is involved in tobacco vein necrosis. [PDF]

PLoS One
Parrella G, Moury B.
europepmc   +1 more source

Family Occurrence of an m.3303C>T Point Mutation in the MT-TL1 Gene, Which Induces Cardiomyopathy Syndrome with/without Skeletal Muscle Myopathy. [PDF]

Genes (Basel)
Fałek O, Wesół-Kucharska D, Starostecka E, Rokicki D, Fortecka-Piestrzeniewicz K, Kępczyński Ł, Piekutowska-Abramczuk D, Ciara E, Maroszyńska I.   +8 more
europepmc   +1 more source

Correction to Supporting Information for Woerman et al., Familial Parkinson's point mutation abolishes multiple system atrophy prion replication. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source