Results 221 to 230 of about 7,351,528 (349)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA. [PDF]

Nat Commun
Aretz J, Jeyasankar G, Salerno-Kochan A, Thomsen M, Thieulin-Pardo G, Haque T, Monteagudo E, Felsenfeld D, Finley M, Vogt TF, Boudet J, Prasad BC.   +11 more
europepmc   +1 more source

FGFR2 point mutation in 2 cases of pleomorphic adenoma progressing to myoepithelial carcinoma. [PDF]

Contemp Oncol (Pozn), 2023
Pikul J, Rzepakowska A, Machnicki M, Stokłosa T.   +3 more
europepmc   +1 more source

Analysis of a point mutation (D152V) in the transcription factor c- Myb and its effect on the interaction of c-Myb with Histone H3 and DNA

, 2007
Pimthanya Wanichawan Drågen
openalex   +1 more source

Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution

, 2020
Naveen Vankadari
openalex   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A single point mutation is sufficient to drive <i>syp</i>-dependent biofilm formation and promote colonization by <i>Vibrio fischeri</i>. [PDF]

J Bacteriol
Fung BL, Musto EG, Mugambi LK, Lange ML, Tepavcevic J, Visick KL.   +5 more
europepmc   +1 more source

Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA

Cell Research, 2012
Hai-Lian Zhou, Qinjian Liu, Jing Li, Dagang Jiang, Lingyan Zhou, Ping Wu, Sen Lu, Feng Li, Liya Zhu, Zhenlan Liu, Letian Chen, Yaoguang Liu, C. Zhuang   +12 more
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A point mutation in the photosystem II protein PsbW disrupts thylakoid organization and alters starch granule formation. [PDF]

Plant Physiol
Ilse TE, Zhang H, Heutinck A, Liu C, Eicke S, Sharma M, Pfister B, Santelia D, Zeeman SC.   +8 more
europepmc   +1 more source