Results 241 to 250 of about 1,268,660 (340)

A Japanese encephalitis virus biological clone with an <i>E</i> gene point mutation exhibits <i>in vitro</i> and <i>in vivo</i> attenuation of neurovirulence. [PDF]

J Gen Virol
Yu SP, Ong KC, Tan SH, Ishikawa T, Perera D, Hooi YT, Wong KT.   +6 more
europepmc   +1 more source

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

, 2009
Esther B. E. Becker, Peter L. Oliver, Maike D. Glitsch, Gareth Banks, Francesca Achilli, Andrea Hardy, Patrick M. Nolan, Elizabeth Fisher, Kay E. Davies   +8 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Formation of CO₂-dependent small-colony variants (SCVs) in methicillin-resistant <i>Staphylococcus aureus</i> mediated by a single point mutation in <i>mpsB</i>. [PDF]

Biofilm
Chen S, Dong W, Li S, Zhong T, Qian X, Cai Y, Ye Y, Liu J, Xu Z, Yuan W.   +9 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

RID is required for both repeat-induced point mutation and nucleation of a novel transitional heterochromatic state for euchromatic repeats. [PDF]

Nucleic Acids Res
He Z, Wu N, Yao R, Tan H, Sun Y, Chen J, Xue L, Chen X, Yang S, Hurst LD, Wang L, Huang J.   +11 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Different Infection Structures and Point Mutation of Diaporthe citri Showing Resistant against Systemic Fungicides. [PDF]

Plant Pathol J
Soe ZZ, Shin YH, Jeun YC.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Single Point Mutation Abolishes Water Capture in Germacradien-4-ol Synthase. [PDF]

Chembiochem
González Requena V, Srivastava PL, Miller DJ, Allemann RK.   +3 more
europepmc   +1 more source