Results 251 to 260 of about 7,351,528 (349)

Characterization of functional effects of point mutations in NEK1 detected in amyotrophic lateral sclerosis on mitochondria and DNA damage response

, 2023
Issayama, Luidy Kasuo, 1993-
openalex   +1 more source

Analyses of displacements resulting from a point mutation in proteins

, 2020
Mathilde Carpentier, Jacques Chomilier
openalex   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

RID is required for both repeat-induced point mutation and nucleation of a novel transitional heterochromatic state for euchromatic repeats. [PDF]

Nucleic Acids Res
He Z, Wu N, Yao R, Tan H, Sun Y, Chen J, Xue L, Chen X, Yang S, Hurst LD, Wang L, Huang J.   +11 more
europepmc   +1 more source

A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.

New England Journal of Medicine, 2011
N. England, M. Bonnie W. Ramsey, M. Jane Davies, N. G. M. Ch.B., Elizabeth Tullis M.D., M. S. C. Bell, Pavel D ř evínek M.D., Matthias Griese M.D., Edward F. McKone M.D., M. C. E. Wainwright, Michael W. Konstan B.S., Richard Moss M.D., Felix Ratjen M.D., Ph. Isabelle Sermet-Gaudelus, Steven M. Rowe Ph.D., Qunming Dong M.S.P.H., Sally Rodriguez Ph.D., M. K. Yen, Claudia Ordoñez M.D., M. J. S. Elborn   +19 more
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Different Infection Structures and Point Mutation of Diaporthe citri Showing Resistant against Systemic Fungicides. [PDF]

Plant Pathol J
Soe ZZ, Shin YH, Jeun YC.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Single Point Mutation Abolishes Water Capture in Germacradien-4-ol Synthase. [PDF]

Chembiochem
González Requena V, Srivastava PL, Miller DJ, Allemann RK.   +3 more
europepmc   +1 more source

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

Nature Network Boston, 2009
N. Malinin, Li Zhang, Jeongsuk Choi, Alieta Ciocea, O. Razorenova, Yan-Qing Ma, E. Podrez, M. Tosi, D. Lennon, A. Caplan, S. Shurin, E. Plow, T. Byzova   +12 more
semanticscholar   +1 more source