Results 261 to 270 of about 7,351,528 (349)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Charge-reversal Point Mutation Completely Depletes Flavin Chromophore from European Robin Cryptochrome 4a Protein

Xu J, Rasmussen ES, Berthias F, Schmidt J, Mouritsen H, Jensen ON, Solov’yov IA.   +6 more
europepmc   +1 more source

A point mutation in a <i>wspF-</i>like gene in <i>Pseudoalteromonas lipolytica</i> enhances the anticorrosion activity. [PDF]

Appl Environ Microbiol
Zeng Z, He D, Zhao Z, He T, Li Q, Wang Y.   +5 more
europepmc   +1 more source

Characterization of Point Mutations in Patients with X-linked Ichthyosis

, 1997
Elisabeth S. Alperin, Larry J. Shapiro
openalex   +1 more source

Repeat-induced point mutation (RIP) as an alternative mechanism of evolution toward virulence in Leptosphaeria maculans.

Molecular Plant-Microbe Interactions, 2009
I. Fudal, S. Ross, H. Brun, Anne-Laure Besnard, M. Ermel, Marie‐Line Kuhn, M. Balesdent, T. Rouxel   +7 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A point mutation in the <i>IAA14</i> promoter enhances callus formation and regeneration. [PDF]

Physiol Mol Biol Plants
Cao H, Zhang X, Li F, Han Z, Ding B.
europepmc   +1 more source

Point Mutation Rate of Bacteriophage ΦX174

Genetics, 2009
J. Cuevas, S. Duffy, R. Sanjuán
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Unraveling MLL1-fusion leukemia: Epigenetic revelations from an iPS cell point mutation. [PDF]

J Biol Chem
Kobrossy L, Xu W, Zhang C, Feng W, Turner CE, Cosgrove MS.   +5 more
europepmc   +1 more source