Results 281 to 290 of about 1,268,660 (340)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Flagellar point mutation causes social aggregation in laboratory-adapted <i>Bacillus subtilis</i> under conditions that promote swimming. [PDF]

J Bacteriol
Alvi S, Mondelo VD, Boyle J, Buck A, Gejo J, Mason M, Matta S, Sheridan A, Kreutzberger MAB, Egelman EH, McLoon A.   +10 more
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

The point mutation A1387G in the 16S rRNA gene confers aminoglycoside resistance in <i>Campylobacter jejuni</i> and <i>Campylobacter coli</i>. [PDF]

Antimicrob Agents Chemother
Zarske M, Werckenthin C, Golz JC, Stingl K.   +3 more
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Synchronous Double Primary Lung Adenocarcinomas With EGFR L858R Point Mutation and MET Exon 14 Skipping Mutation. [PDF]

J Med Cases
Ando S, Futami S, Azuma K, Nishimatsu K, Shirasaka T, Minami S.   +5 more
europepmc   +1 more source

A new point mutation in the HC-Pro of potato virus Y is involved in tobacco vein necrosis. [PDF]

PLoS One
Parrella G, Moury B.
europepmc   +1 more source

Family Occurrence of an m.3303C>T Point Mutation in the MT-TL1 Gene, Which Induces Cardiomyopathy Syndrome with/without Skeletal Muscle Myopathy. [PDF]

Genes (Basel)
Fałek O, Wesół-Kucharska D, Starostecka E, Rokicki D, Fortecka-Piestrzeniewicz K, Kępczyński Ł, Piekutowska-Abramczuk D, Ciara E, Maroszyńska I.   +8 more
europepmc   +1 more source

GTP-Bound N-Ras Conformational States and Substates Are Modulated by Membrane and Point Mutation. [PDF]

Int J Mol Sci
Farcas A, Janosi L.
europepmc   +1 more source