Results 311 to 320 of about 6,585,062 (339)

Point Mutational Inactivation of the Retinoblastoma Antioncogene

Science, 1989
The retinoblastoma (Rb) antioncogene encodes a nuclear phosphoprotein, p105-Rb, that forms protein complexes with the adenovirus E1A and SV40 large T oncoproteins. A novel, aberrant Rb protein detected in J82 bladder carcinoma cells was not able to form a complex with E1A and was less stable than p105-Rb. By means of a rapid method for the detection of
Thaddeus P. Dryja, Ed Harlow, David W. Yandell, Jonathan M. Horowitz, Robert A. Weinberg, Sang Ho Park, Karen J. Buchkovich, Susan Canning, Peter Whyte   +8 more
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Point Mutations and Radiation Carcinogenesis

Radiation Research, 1991
In his recent summary of a symposium, Fry (1) poses the question: "Are deletions and perhaps changes in suppressor genes more important in radiation carcinogenesis than are point mutations?" Microdosimetric considerations indicate that this should, at least frequently, be the case.
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Correcting tyrosinaemia via a point mutation

Nature Biomedical Engineering, 2020
In an adult mouse model of tyrosinaemia, a base editor correcting an A-to-G splice-site mutation in the Fah gene restores the translation of the functional enzyme, promoting the repopulation of the liver with the corrected cells.
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Singling-out point mutations

Drug Discovery Today, 2005
LigAmp is a new technique for identifying point mutations in DNA and could be a new tool for diagnosing and managing diseases.
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Evolving beyond point mutations

Trends in Ecology & Evolution, 2002
Genomic structure and content are remarkably labile over evolutionary time. Yet we know little about the relative importance of genomic changes versus point mutations in adaptive evolution. Using microarray technology, a new paper [1xGenetic architecture of thermal adaptation in Escherichia coli. Riehle, M.M. et al. Proc. Natl. Acad. Sci. U. S. A. 2001;
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Point mutations and human hemoglobin variants

Human Genetics, 1969
More than one hundred hemoglobin variants with single amino acid substitutions give information about point mutations in the DNA structure of the hemoglobin cistrons.
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Pathological role of a point mutation (T315I) in BCR‐ABL1 protein—A computational insight

Journal of Cellular Biochemistry, 2018
V. Rajendran, Chandrasekhar Gopalakrishnan, R. Sethumadhavan   +2 more
semanticscholar   +1 more source

Point mutations in the FLT3 gene in AML

Blood, 2001
Approximately 20% of acute myeloid leukemia (AML) patients have been found to have constitutive activation of the FLT3-receptor tyrosine kinase due to internal tandem duplications of the juxtamembrane domain (FLT3-ITD).
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Impact of point mutation P29S in RAC1 on tumorigenesis

Tumor Biology, 2016
V. Rajendran, Chandrasekhar Gopalakrishnan, Rituraj Purohit   +2 more
semanticscholar   +1 more source

Point mutations in human neoplasia

The Journal of Pathology, 1988
Stanley R. Hamilton, Bert Vogelstein
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