Results 81 to 90 of about 811,999 (309)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Admission Point-of-Care Testing for the Clinical Care of Children with Cerebral Malaria

Tropical Medicine and Infectious Disease
Point-of-care testing (PoCT), an alternative to laboratory-based testing, may be useful in the clinical care of critically ill children in resource-limited settings.
David Wichman, Geoffrey Guenther, Nthambose M. Simango, Mengxin Yu, Dylan Small, Olivia D. Findorff, Nathaniel O. Amoah, Rohini Dasan, Karl B. Seydel, Douglas G. Postels, Nicole F. O’Brien   +10 more
doaj   +1 more source

Blood Gas Measurements Using Point-of-Care Testing Devices in Pediatric Patients [PDF]

Introduction: There is an increasing use of point-of-care testing (POCT) devices for patients. These portable devices are preferred by healthcare personnel because they are quick and easy to use.
Duygu Teksöz, Murat Koşer, Nilgün Işıksaçan   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Comparative evaluation of HbA1c in point-of-care testing (POCT) devices: enzymatic and immunoassay methods compared to ion-exchange high-performance liquid chromatography (IE-HPLC)

Medicinski Glasnik
Aim To evaluate 3 point-of-care testing (POCT) devices in testing HbA1c: the Simplex TASTM101 (Tascom Co. Ltd., South Korea), which utilizes an enzymatic method, and two immunoassay-based devices, the Zybio Q8 Pro and Zybio EXR 110 (Zybio Inc., China ...
Windradini Rahvian Aridama, Ferdy Royland Marpaung, Yessy Puspitasari   +2 more
doaj   +1 more source

The cost-effectiveness of upfront point-of-care testing in the emergency department: a secondary analysis of a randomised, controlled trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019
Background Time-saving is constantly sought after in the Emergency Department (ED), and Point-of-Care (POC) testing has been shown to be an effective time-saving intervention.
Lara Nicole Goldstein, Mike Wells, Craig Vincent-Lambert   +2 more
doaj   +1 more source

Clinical evaluation and cross-validation of the point-of-care system istat at the emergency department versus central laboratory analysis

, 2014
BACKGROUND: In the emergency department (ED), large numbers of blood samples are taken on a daily basis. Owing to their ability to produce rapid results, point-of-care (POC) analysis systems are applied increasingly in the ED.
Schilling, Ulf Martin,
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Point-of-care testing for sexually transmitted infections in low- and middle-income countries: a scoping review protocol

, 2020
Objective: This review will explore how point-of-care tests for sexually transmitted infections have been implemented into health care systems in low- and middle-income countries, and the facilitators and barriers to implementation.
Jaime H. Vera, Kevin Martin, Tom Roper, Jaime Vera Rojas (4466536), Tom Roper (8490414), Kevin Martin (3007044)   +5 more
core   +1 more source

Enhanced Sensing Behavior of Three-Dimensional Microfluidic Paper-Based Analytical Devices (3D-μPADs) with Evaporation-Free Enclosed Channels for Point-of-Care Testing

, 2021
Despite the potential in fabrication of microfluidic paper-based analytical devices (μPADs) for point-of-care testing (POCT) kits, the development of simple, accurate, and rapid devices with higher sensitivity remains challenging. Here, we report a novel
Jaehyung Jeon, Chanyong Park, Dinesh Veeran Ponnuvelu, Sungsu Park   +3 more
core   +1 more source