Results 101 to 110 of about 3,696,026 (267)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

User-based clustering deep model for the sequential point-of-interest recommendation

open access: yes
The point-of-interest (POI) recommendation is a key function of location-based social networks that can help users exploit unfamiliar areas. Due to the massive check-in records accumulated in these location-based applications, the sequential POI ...
Wang, Can   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Delta and Gamma hedging of mortality and interest rate risk [PDF]

open access: yes
This paper studies the hedging problem of life insurance policies, when the mortality and interest rates are stochastic. We focus primar- ily on stochastic mortality. We represent death arrival as the rst jump time of a doubly stochastic process, i.e.
Elisa Luciano, Luca Regis, Elena Vigna
core  

A Low Complexity Interest Point Detector

open access: yes, 2015
Interest point detection is a fundamental approach to feature extraction in computer vision tasks. To handle the scale invariance, interest points usually work on the scale-space representation of an image.
Duan, Ling-Yu   +5 more
core   +1 more source

Urban Grid Population Inflow Prediction via POI-Enhanced Conditional Diffusion with Dual-Dimensional Attention

open access: yesISPRS International Journal of Geo-Information
Accurate prediction of urban grid-scale population inflow is crucial for smart city management and emergency response. However, existing methods struggle to model spatial heterogeneity and quantify prediction uncertainty, limiting their accuracy and ...
Zhiming Gui, Yuanchao Zhong, Zhenji Gao
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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