Results 121 to 130 of about 3,696,026 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Evaluation of 3D Interest Point Detection Techniques
, 2011 In this paper, we compare the results of five 3D interest point detection techniques to the interest points marked by human subjects. This comparison is used to quantitatively evaluate the interest point detection algorithms.
Dutagaci, Helin +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Profitability of Interest-free vs. Interest-based Banks in Turkey
Islamic banking is consistent with Islamic law and guided by Islamic economics. They are prohibited from charging or paying interest, and can operate only on the basis of the profit-sharing arrangements.
Durmaz, Nazif, Soylu, Ali
core
PERBAIKAN KUALITAS KELUHAN GASTRITIS AKUT MENGGUNAKAN AQUAPUNKTUR TITIK ZULANLI DAN TITIK DIJI
, 2012 : Aquapunktur, Zusanli Point, Point Diji, Complaints Gastritis. The purpose of this study is the effectiveness of therapy aquapuntur between Zulanli point (St. 36) and points Diji (sp.
Kusumawati, Heni Nur +2 more
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Extraction of urban built-up area based on the fusion of night-time light data and point of interest data. [PDF]
R Soc Open Sci, 2021 He X, Zhang Z, Yang Z.
europepmc +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
GeographiesThe COVID-19 pandemic profoundly affected people’s travel behavior and travel desires, particularly regarding trips to prominent destinations. This study explores the pandemic’s impact on travel behavior and online search patterns for 12 landmarks across
Jiping Cao +3 more
doaj +1 more source