Results 161 to 170 of about 11,269,614 (288)

Marked point process variational autoencoder with applications to unsorted spiking activities. [PDF]

PLoS Comput Biol
Shibue R, Iwata T.
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

How to make use of unlabeled observations in species distribution modeling using point process models. [PDF]

Ecol Evol, 2021
Guilbault E, Renner I, Mahony M, Beh E.
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Continuous-Time Causal Inference With Marked Point Process Weights: An Example on Sodium-Glucose Co-Transporters 2 Inhibitor Medications and Urinary Tract Infection. [PDF]

Stat Med
Kalia S, Saarela O, Chen T, O'Neill B, Meaney C, Moineddin R, Aliarzadeh B, Sullivan F, Greiver M.   +8 more
europepmc   +1 more source

Real-Time Point Process Filter for Multidimensional Decoding Problems Using Mixture Models. [PDF]

J Neurosci Methods, 2021
Rezaei MR, Arai K, Frank LM, Eden UT, Yousefi A.   +4 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times. [PDF]

Biol Cybern, 2021
Peterson AJ.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Marked Point Process Secretory Events Statistically Characterize Leptin Pulsatile Dynamics. [PDF]

J Endocr Soc
Xiang Q, Reddy R, Faghih RT.
europepmc   +1 more source