Results 141 to 150 of about 3,602,130 (312)
A Process-Based Model of New Venture Creation: Toward Modelling a Practical Application of Extant Theory using SADT Diagrams [PDF]
, 2011 Although the field of entrepreneurship abounds in studies attempting to explain the creation of new ventures from an array of theoretical perspectives, the answer to the critical question regarding “how” the process unfolds over time remains unsolved ...
DUBOIS, Patrice +2 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The limit theorems on extreme order statistics and partial sums of i.i.d. random variables
Open MathematicsThis article proves several weak limit theorems for the joint version of extreme order statistics and partial sums of independently and identically distributed random variables. The results are also extended to almost sure limit version.
Li Gaoyu, Ling Chengxiu, Tan Zhongquan
doaj +1 more source
Mediating between modeled and observed behavior : the quest for the "right" process
, 2013 Operational processes leave trails in the information systems supporting them. Such event data are the starting point for process mining - an emerging scientific discipline relating modeled and observed behavior.
Cavarero, J.-L. +4 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A flexible and efficient Bayesian implementation of point process models for spatial capture-recapture data. [PDF]
Ecology, 2023 Zhang W +6 more
europepmc +1 more source