Results 51 to 60 of about 12,014 (293)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Mathematics, 2020 The theory of point vortices is used to explain the interaction of a surface vortex with subsurface vortices in the framework of a three-layer quasigeostrophic model.
Mikhail A. Sokolovskiy +2 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
LOCALIZED VORTICES IN TWO-DIMENSIONAL HYDRODYNAMIC MEDIA
East European Journal of Physics, 2015 The review covers the main achievements in the field of the dynamics of strongly localized vortices in two-dimensional hydrodynamic media. The types of point vortices and their motion equations are discussed.
V. V. Yanovsky, A. V. Tur, K. N. Kulik
doaj
A new member of the structured light family: optical spatiotemporal vortices
Light: Science & Applications, 2023 The burgeoning growth of structured light has opened up new possibilities for harnessing the spatiotemporal coupling effects in light. Optical spatiotemporal vortices, as a subset of spatiotemporal light, have emerged as a focal point of recent research,
Fu Feng, Xiaocong Yuan
doaj +1 more source
Brownian point vortices and dd-model
Discrete and Continuous Dynamical Systems - S, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Kinetic theory of two-dimensional point vortices and fluctuation–dissipation theorem [PDF]
, 2023 International audienceWe complete the kinetic theory of two-dimensional (2D) point vortices initiated in previous works. We use a simpler and more physical formalism.
Chavanis, Pierre-Henri
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Modelling vortex-vortex and vortex-boundary interaction [PDF]
, 2010 The motion of two-dimensional inviscid, incompressible fluid with regions of constant vorticity is studied for three classes of geophysically motivated problem. First, equilibria consisting of point vortices located near a vorticity interface generated
Nelson, R.B.
core