Results 181 to 190 of about 835,873 (364)

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

open access: yesAdvanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu   +12 more
wiley   +1 more source

Tunneling Nanotube‐Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury

open access: yesAdvanced Science, EarlyView.
ROS accumulation is an important upstream signal for activating transcellular autophagy. Incomplete autophagy and TNT formation are necessary conditions for activating transcellular autophagy, and the disruption of the autophagic fusion mechanism is a trigger for activating transcellular autophagy.
Tao Wang   +13 more
wiley   +1 more source

Electrocatalytic Hydrogen Oxidation by Defect‐Enriched CuW Nanoalloy Featuring Hydrogen Spillover Effect

open access: yesAdvanced Science, EarlyView.
The CuW nanoalloy is synthesized via electrodeposition, with the coexistence of Cu, W/WO3 enhancing hydrogen spillover and improving hydrogen oxidation. W/WO3 facilitates hydrogen adsorption, whereas Cu supports hydrogen spillover and oxidation catalysis.
Bingyan Xiong, Lisong Chen, Jianlin Shi
wiley   +1 more source

Co‐Selection of Low Cadmium Accumulation and High Yield During Tomato Improvement

open access: yesAdvanced Science, EarlyView.
This study finds that large‐fruited tomatoes accumulate less cadmium (Cd) compared to wild tomatoes and cherry tomatoes. This is because, during the improvement process of tomato, the low‐Cd allele LCT1A and the large fruit allele fw3.2T are closely linked, leading to a co‐selection event.
Xingyu Zhang   +11 more
wiley   +1 more source

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