Results 191 to 200 of about 489,664 (384)

On the Poisons of Amanita Phalloides

open access: hybrid, 1907
John J. Abel, William W. Ford
openalex   +1 more source

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

open access: yesAdvanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li   +24 more
wiley   +1 more source

Cytokine Storm Induction Linked to Multi‐Organ Failure in Fatal Jellyfish Stings

open access: yesAdvanced Science, EarlyView.
N. nomurai is the most important injurious species in the coastal area of China. Model construction, omics analysis, mechanism exploration, and intervention measures of N. nomurai envenomation are performed in the current study, and it suggested that cytokine storm played an important role in pathogenesis.
Yichao Wang   +15 more
wiley   +1 more source

Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening

open access: yesAdvanced Science, EarlyView.
Human nervous system‐based biohybrid robot‐on‐a chip with eye function as sensing system in addition to brain/motor neuron/muscle functions is proposed. Upon light stimulation, the eye assembloid generates electrophysiological signals, which are transmitted through the cerebral organoid and motor neuron spheroid, inducing muscle movement.
Minkyu Shin   +6 more
wiley   +1 more source

Conditioned taste aversions: From poisons to pain to drugs of abuse

open access: yesPsychonomic Bulletin & Review, 2017
Jian-You Lin, Joe Arthurs, S. Reilly
semanticscholar   +1 more source

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