Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons. [PDF]
, 2016 Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits.
Butchbach, Matthew E.R. +7 more
core +2 more sources
What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications
Biosensors, 2019 This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis.
Paloma Yáñez-Sedeño +3 more
doaj +1 more source
Extracorporeal Treatment for Poisoning [PDF]
Revista Portuguesa de Nefrologia e Hipertensão, 2022 Accidental or intentional poisoning and drug overdose are a significant source of morbidity, mortality and health care expenditure worldwide. Extracorporeal removal treatments have been used to treat poisoning for decades and different modalities are ...
Catarina Cardoso, Sílvia Coelho
doaj +1 more source
Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives
International Journal of Molecular Sciences, 2018 Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to the protein.
Jessica Marinello +2 more
semanticscholar +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2020 Envenomations by colubrid snakes in Colombia are poorly known, consequently, the clinical relevance of these species in snakebite accidents has been historically underestimated.
Teddy Angarita-Sierra +3 more
doaj +1 more source
Burnable Poison Selection and Neutronics Analysis of Plate Fuel Assemblies
Frontiers in Energy Research, 2021 Burnable poisons play a critical role in long-life pressurized water reactors. Plate fuel elements have good application prospects in long-life pressurized water reactors.
Shikun Xu +9 more
doaj +1 more source
TDP1/TOP1 ratio as a promising indicator for the response of small cell lung cancer to topotecan [PDF]
, 2014 BACKGROUND AND OBJECTIVE Small cell lung cancer (SCLC) is one of the most challenging tumors to treat due to high proliferation rate, early metastatic dissemination and rapid development of chemotherapy resistance.
El-Khamisy, Sherif F +3 more
core +3 more sources
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]
, 2012 The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma +36 more
core +1 more source
Delayed Acetaminophen Absorption Resulting in Acute Liver Failure
Case Reports in Critical Care, 2022 Introduction. Acetaminophen is a common medication involved in deliberate and accidental self-poisoning. The acetaminophen treatment nomogram is used to guide acetylcysteine treatment.
Huiling Tan +4 more
doaj +1 more source
Understanding Poison: Study of a Word Du from the Perspective of Comparative History
Chinese Medicine and Culture, 2023 This article investigates the word Du (毒) in premodern Chinese medicine and culture. It highlights the paradoxical meaning of the word that served as a foundation for the therapeutic use of poisons in traditional Chinese medicine.
Yan LIU
doaj +1 more source