Results 221 to 230 of about 415,924 (312)

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Molecular sampling limits of ctDNA detection in clinical plasma samples. [PDF]

J Liq Biopsy
Gamisch A.
europepmc   +1 more source

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source

Body mass index modifies the association between occupational noise exposure duration and ultrasound‑detected hepatic steatosis: A cross-sectional study among male factory workers. [PDF]

PLoS One
Liu D, Ji H, Chen Y, Zhou T.
europepmc   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Unjustified Poisson assumptions lead to overconfident estimates of the effective reproductive number. [PDF]

Epidemiol Infect
Němcová B, Goldstein IH, Sebastian J, Minin VM, Bracher J.   +4 more
europepmc   +1 more source

Origami Metamaterials Based on Low‐Melting‐Point Alloy Phase Transition: Breaking the Trade‐Off Between Reusability and Energy Absorption Quality

Advanced Science, EarlyView.
This work presents an origami metamaterial that integrates a low‐melting‐point alloy skeleton into an elastomeric shell. It dissipates energy through the metal's plastic deformation and recovers through the solid–liquid phase transition of the alloy together with the hyperelasticity of the shell.
Yupeng Liu, Wei Zhao, Chengjun Zeng, Jiuming Fan, Yanju Liu, Jinsong Leng   +5 more
wiley   +1 more source

Spiking neural models for decision-making tasks with learning. [PDF]

J Math Biol
Jaffard S, Mezzadri G, Reynaud-Bouret P, Tanré E.   +3 more
europepmc   +1 more source

Charge‐Transfer‐Mediated Boron Magneto‐Ionics: Towards Voltage‐Driven Multi‐Ion Transport

Advanced Science, EarlyView.
This study demonstrates voltage‐driven multi‐ion transport in FeBO systems, revealing simultaneous motion of B, Fe, and O ions enabled by charge‐transfer effects. By tuning oxidation states through oxygen incorporation, we achieve a transition from electrostatic‐like to electrochemical magneto‐ionic behavior. The findings establish boron magneto‐ionics,
Zheng Ma, Karim‐Alexandros Kantre, Huan Tan, Aitor Arredondo‐López, Maciej O. Liedke, Javier Herrero‐Martín, Eric Hirschmann, Andreas Wagner, Daniel Mora‐Blanco, Alberto Quintana, Salvador Pané, Eva Pellicer, Josep Nogués, Johan Meersschaut, Jordi Sort, Enric Menéndez   +15 more
wiley   +1 more source

Review of La qualité de l'enseignement supérieur au Québec

Canadian Journal of Higher Education, 1994
Yves Poisson
doaj   +1 more source