Results 101 to 110 of about 52,277 (298)

Can Polar fish get out of breath? Hypoxia tolerance and aerobic scope of Polar cod, Boreogadus saida

, 2021
The effects of climate change are projected to be most severe changes in Arctic environments. Warming has already caused various environmental changes, including a loss of almost 50% Arctic sea-ice coverage since the 1980s. Sea-ice loss strengthens summer stratification and, consequently, hypoxic zones in the deep-water layers may form.
Mark, Felix Christopher, Kempf, Sarah, Neven, Carolin J., Claireaux, Guy   +3 more
openaire   +4 more sources

Experimental and analytical study of cracks under biaxial fatigue [PDF]

, 2016
Most mechanical components experience multi-axial cyclic loading conditions during service. Experimental analysis of fatigue cracks under such conditions is not easy and most works tend to focus more on the simpler but less realistic case of uni-axial ...
Camas, Daniel, Lopez-Crespo, Pablo, Lopez-Moreno, A, Mokhtarishirazbad, M, Moreno-Morales, Maria Belen, Zanganeh, M   +5 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Enhanced removal of nano-oil droplets utilizing polysilicate aluminum ferric (PSAF): Leveraging bridging and non-polar surface advantages

Water Science and Technology
Hydraulic oil leaks during mechanical maintenance, resulting in flushing wastewater contaminated with dispersed nano-oil droplets. In this study, 75 mg L−1 of polysilicate aluminum ferric (PSAF) was stirred at 350 rpm and the optimal chemical oxygen ...
Yadan Liu, Yanjun Zhou, Hui Su, Chao Gu, Botao Shangguan, Zhiyang Yan, Jinyi Qin   +6 more
doaj   +1 more source

Status and biology of harbour seals (Phoca vitulina) in Svalbard

NAMMCO Scientific Publications, 2010
Harbour seals in Svalbard are the northernmost population of this species. This small population is comprised of ca. 1,000 individuals, most of which reside along the west coast of Prins Karls Forland (78°20’N). Satellite tracking studies have shown that
Christian Lydersen, Kit M Kovacs
doaj   +1 more source

2018 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Eco-Toxicity and Sublethal Impacts [PDF]

, 2018
Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core   +1 more source

Ketone Hydrogenation with Iridium Complexes with “non N–H” Ligands: The Key Role of the Strong Base [PDF]

, 2015
Ferrocenyl phosphine thioether ligands (PS), not containing deprotonatable functions, efficiently support the iridium catalyzed ketone hydrogenation in combination with a strong base co-catalyst. Use of an internal base ([Ir(OMe)(COD)]2 in place of [IrCl(
Deydier, Eric, Hayes, Joseph M., Lledós, Agustí, Malacea-Kabbara, Raluca, Manoury, Eric, Poli, Rinaldo, Ujaque, Gregori, Vincendeau, Sandrine   +7 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of dispersed fuel oil on cardiac mitochondrial function in polar cod Boreogadus saida

Environmental Science and Pollution Research, 2014
In this study, impact of dispersed oil on cardiac mitochondrial function was assessed in a key species of Arctic marine ecosystem, the polar cod Boreogadus saida. Mature polar cod were exposed during 48 h to dispersed oil (mechanically and chemically) and dispersants alone.
Matthieu, Dussauze, Lionel, Camus, Stéphane, Le Floch, Karine, Pichavant-Rafini, Perrine, Geraudie, Nathalie, Coquillé, Aline, Amérand, Philippe, Lemaire, Michael, Theron   +8 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source