Results 51 to 60 of about 12,498 (259)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

On Some Natures of the Excitation and Damping of the Polar Motion [PDF]

Symposium - International Astronomical Union, 1972
Values of the Chandlerian period and the damping coefficient of the polar motion are calculated for every ten years from 1900.0 to 1970.0, using a method developed by Sekiguchi (1966). The damping coefficient is variable between 0.074 and 0.008 (yr)−1 through this period, and correlative with the variation of the Chandlerian period, as Sekiguchi (1961)
openaire   +1 more source

Long‐term polar motion excited by ocean thermal expansion [PDF]

Geophysical Research Letters, 2009
Ocean warming is commonly considered unable to excite significant long‐term trends in polar motion. Here, however, we argue that this assumption needs to be revised. We demonstrate that steric sea level rise leads to a distinct pattern of horizontal mass redistribution within ocean basins and hence to ocean bottom pressure changes that alter Earth's ...
Landerer, F., Jungclaus, J. ; https://orcid.org/0000-0002-3849-4339, Marotzke, J.   +2 more
openaire   +2 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Can we estimate the period and quality-factor of the Chandler wobble using only the observed polar motion data?

Earth, Planets and Space
The clear ~ 6-year beat in the polar motion data has allowed us to consider the Chandler period (P) as ~ 1.2 years, albeit approximately, from solely the observed polar motion data.
Ryuji Yamaguchi, Masato Furuya
doaj   +1 more source

Study on sloshing simulation in the independent tank for an ice-breaking LNG carrier

International Journal of Naval Architecture and Ocean Engineering, 2020
As the LNG carrier operates in ice covered waters, it is key to ensure the overall safety, which is related to the coupling effect of ice-breaking process and internal liquid sloshing. This paper focuses on the sloshing simulation of the ice-breaking LNG
Shifeng Ding, Gang Wang, Qiuming Luo
doaj   +1 more source

Preliminary study on hydrological angular momentum determined from CMIP6 historical simulations

Earth, Planets and Space, 2022
Polar motion (PM) is an essential parameter needed to transform coordinates between celestial and terrestrial reference frames, thus playing a crucial role in precise positioning and navigation.
Jolanta Nastula, Justyna Śliwińska, Tomasz Kur, Małgorzata Wińska, Aleksander Partyka   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Consistent atmospheric and oceanic excitation of the Earth's free polar motion [PDF]

Geophysical Journal International, 2004
SUMMARY Earth orientation parameters as observed by space-geodetic techniques show a broad spectrum of frequencies. Many efforts have been made to relate spectral peaks to geophysical processes, such as atmospheric or oceanic variations. However, the mechanisms of excitation of some typical oscillations are still unclear.
Seitz, F., Struck, J., Thomas, M.
openaire   +3 more sources