Results 81 to 90 of about 19,795 (292)

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Polarization-Insensitive Remote Access Unit for Radio-Over-Fiber Mobile Fronthaul System by Reusing Polarization Orthogonal Light Waves

IEEE Photonics Journal, 2016
To reduce the complexity and cost of remote access units (RAUs), colorless transport architecture is preferred in a wavelength-division multiplexing (WDM) system. The wavelength-reuse technique is commonly adopted to realize colorless RAUs.
Beilei Wu, Jiun-Yu Sung, Jhih-Heng Yan, Mu Xu, Jing Wang, Fengping Yan, Shuisheng Jian, Gee-Kung Chang   +7 more
doaj   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Empowering high-dimensional optical fiber communications with integrated photonic processors

Nature Communications
Mode-division multiplexing (MDM) in optical fibers enables multichannel capabilities for various applications, including data transmission, quantum networks, imaging, and sensing.
Kaihang Lu, Zengqi Chen, Hao Chen, Wu Zhou, Zunyue Zhang, Hon Ki Tsang, Yeyu Tong   +6 more
doaj   +1 more source

Silicon photonic transmitter and receiver for hybrid multiplexing systems

Chip
High-capacity on-chip optical transmitters and receivers are crucial for data transmissions. Currently, advanced multiplexing technologies, including wavelength division multiplexing (WDM), mode-division multiplexing (MDM), and polarization-division ...
Yingying Peng, Hengzhen Cao, Jin Xie, Weike Zhao, Yuluan Xiang, Dajian Liu, Zejie Yu, Daoxin Dai   +7 more
doaj   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Comb-based WDM transmission at 10 Tbit/s using a DC-driven quantum-dash mode-locked laser diode

, 2019
Chip-scale frequency comb generators have the potential to become key building blocks of compact wavelength-division multiplexing (WDM) transceivers in future metropolitan or campus-area networks.
Abderrahim Ramdane, Akrout, Anandarajah, Ataie, Calò, Christian Koos, Di Domenico, Fatadin, François Lelarge, Fülop, Godard, Godone, Hillerkuss, Hu, Huynh, Juned N. Kemal, Kamel Merghem, Kemal, Kikuchi, Lelarge, Leven, Lu, Magarini, Maldonado-Basilio, Marin-Palomo, Mercer, Moscoso-Mártir, Müller, Pablo Marin-Palomo, Pfau, Pfeifle, Pfeifle, Philipp Trocha, Pillai, Rodrigo-Navarro, Rosales, Rosales, Rosales, Savory, Schmogrow, Sebastian Randel, Stefan Wolf, Thompson, Torres-Company, Vedala, Winzer, Wolfgang Freude, Zhang   +47 more
core   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

W-Band PDM-QPSK Vector Signal Generation by MZM-Based Photonic Frequency Octupling and Precoding

IEEE Photonics Journal, 2015
We experimentally demonstrate polarization-division-multiplexing quadrature-phase-shift-keying (PDM-QPSK) modulated vector signal generation at the W-band, adopting Mach-Zehnder-modulator-based (MZM-based) photonic frequency octupling and phase precoding
Xinying Li, Jianjun Yu, Jiangnan Xiao, Nan Chi, Yuming Xu   +4 more
doaj   +1 more source