Results 101 to 110 of about 19,948 (281)

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang, Fengqin Wang, Lanlan Liu, Qi Zhang, Xiaoning Huo, Yanhui Nan, Yanli Dong, Yunling Xiao, Jing Hao   +8 more
wiley   +1 more source

Memristive Physical Reservoir Computing

Advanced Science, EarlyView.
Memristors’ nonlinear dynamics and input‐dependent memory effects make them ideal candidates for high‐performance physical reservoir computing (RC). Based on their conductance modulation, memristors can be classified as electronic or optoelectronic types.
Dian Jiao, Ziyuan Wang, Jingrui Wang, Li Zhang, Xianhua Wei, Lingxiang Hu, Zongxiao Li, Athanasios V. Vasilakos, Zhizhen Ye, Fei Zhuge   +9 more
wiley   +1 more source

A Soft Mechanoluminescent Skin for High‐Resolution Optical Tactile Sensing in Human–Machine Interaction

Advanced Science, EarlyView.
A soft mechanoluminescent tactile sensor that converts force directly into light is presented, enabling imaging‐based, wiring‐free touch sensing. By integrating a flexible ML‐skin with CMOS readout, the system achieves high sensitivity, fast response, and high spatial resolution, while maintaining structural simplicity and energy efficiency, offering a
Yu Feng, Qiaojiao Wang, Yehui Liu, Jiankun Li, Senlin Hou, Xiaomeng Yang, Ziyi Li, Yanji Yi, Meng Chen, Guanglie Zhang, Hao Sun, Wen Jung Li   +11 more
wiley   +1 more source

Terahertz‐Wave Polarization Space‐Division Multiplexing Meta‐Devices based on Spin‐Decoupled Phase Control

Advanced Science
This study presents a generalized design strategy for novel terahertz‐wave polarization space‐division multiplexing meta‐devices, functioning as multi‐polarization generators, modulators, and analyzers.
Yuehong Xu, Yuma Takida, Tetsu Suzuki, Hiroaki Minamide   +3 more
doaj   +1 more source

Over 100 Gb/s Ultrabroadband MIMO Wireless Signal Delivery System at the D-Band

IEEE Photonics Journal, 2016
We propose and experimentally demonstrate an ultrabroadband wireless millimeter-wave (mm-wave) signal delivery system at the D-band (110–170 GHz), employing the techniques of photonics-aided mm-wave generation, wireless multiple-input ...
Xinying Li, Jianjun Yu
doaj   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Design and Simulation of Cross-Medium Two-Hop Relaying Free-Space Optical Communication System Based on Multiple Diversity and Multiplexing Technologies

Photonics
To address the issues of link mismatch and channel impairment in wireless optical communication across atmospheric-oceanic media, this paper proposes a two-hop relay transmission architecture based on the multiple-input multiple-output (MIMO)-enhanced ...
Min Guo, Pengxiang Wang, Yan Wu
doaj   +1 more source

A combined scheme of polarization mode dispersion compensation and polarization de-multiplexing in a polarization division multiplexing system with direct detection

Acta Physica Sinica, 2013
A model of polarization mode dispersion (PMD) and state of polarization (SOP) variation induced coherent crosstalk is established in a polarization division multiplexing system. The properties of radio frequency power of one channel in the presence of PMD are investigated.
null Lin Jia-Chuan, null Xi Li-Xia, null Zhang Xia, null Tian Feng, null Liang Xiao-Chen, null Zhang Xiao-Guang   +5 more
openaire   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source