Results 181 to 190 of about 20,155 (297)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

Chiral valley edge states based on Dirac mass engineering. [PDF]

open access: yesNat Commun
Liu JW   +9 more
europepmc   +1 more source

Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles

open access: yesSmall, EarlyView.
This study introduces a dual‐labeled gold nanoparticle model to capture particle–responsive cells via integrating fluorescence‐activated cell sorting and single‐cell RNA sequencing. Fourteen macrophage subsets are identified with response and function heterogeneity, among which AMs_3, AMs_7, and recMacs_4 subsets show stronger phagocytic activation ...
Qing'e Shan   +11 more
wiley   +1 more source

Inferring cumulative crack widths in reinforced concrete structures using Coda Wave Interferometry of ultrasound

open access: yesStructural Concrete, EarlyView.
Abstract Whether concrete structures are cracked, how wide these cracks are, and whether they must be regarded as damaging, is a central issue in structural health monitoring. Ultrasonic measurements evaluated with the sensitive Coda Wave Interferometry (CWI) have the potential to detect cracks early—long before they become visible. This paper presents
Felix Clauß   +3 more
wiley   +1 more source

Exploring the impact of microbial dysbiosis on ovarian cancer and the therapeutic potential of probiotics

open access: yesVIEW, EarlyView.
Ovarian cancer has been linked to the microbiome as a potential environmental contributor, but how this association relates to tumor progression remains unclear. By comparing tumor and nontumor tissues, we identified a severity‐associated microbial and metabolic signature and showed that probiotics can partially restore immune balance and slow tumor ...
Chanyuan Li   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy