Results 31 to 40 of about 2,727 (214)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Сompensator of polarization mode dispersion based on spiral-wound single-mode fiber [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2013
A polarization mode dispersion (PMD) compensator for single-mode optical fiber has been designed. Its operation principle is based on the use of artificial difference of phase velocities of the basic ordinary and extraordinary waves in spiral-wound fiber,
Bagachuk D. G.
doaj   +2 more sources

Polarization Division Multiplexing CV-QKD with Pilot-Aided Polarization-State Sensing

Mathematics
Continuous-variable quantum key distribution (CV-QKD) with local local oscillator (LLO) is well-studied for its security and simplicity, but enhancing performance and interference resistance remains challenging.
Zicong Tan, Tao Wang, Yuehan Xu, Xu Liu, Lang Li, Beibei Zhang, Yuchao Liu, Peng Huang, Guihua Zeng   +8 more
doaj   +1 more source

Nonlinear Impairment Compensation for Polarization-Division Multiplexed WDM Transmission Using Digital Backward Propagation

IEEE Photonics Journal, 2009
It is shown experimentally that impairments induced by dispersion and Kerr nonlinearity can be compensated digitally for polarization-division multiplexed wavelength division multiplexing (WDM) transmission.
F. Yaman, Guifang Li
doaj   +1 more source

Thermally Tunable Orbital Angular Momentum Mode Generator Based on Dual-Core Photonic Crystal Fibers

Nanomaterials, 2021
The combination of mode division multiplexing (MDM) based on orbital angular momentum (OAM) modes with wavelength division multiplexing (WDM) has attracted considerable attention due to its ability to increase optical transmission capacity.
Lianzhen Zhang, Xuedian Zhang, Xuejing Liu, Jun Zhou, Na Yang, Jia Du, Xin Ding   +6 more
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Feasibility of polarization division multiplexing for bidirectional optical links in 5G radio-over-fiber cloud access networks

Investigación e Innovación en Ingenierías
Objective: to investigate the potential of polarization division multiplexing in a 5G radio-over-fiber cloud access network to enable bidirectional optical links in the front-haul segment. Methodology: an optically centralized cloud radio access network
Gustavo Puerto Leguizamón, Carlos Arturo Suárez Fajardo   +1 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source